Mistranslation can enhance fitness through purging of deleterious mutations
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15410
Abstract: Phenotypic mutations are amino acid changes caused by mistranslation. How phenotypic mutations affect the adaptive evolution of new protein functions is unknown. Here we evolve the antibiotic resistance protein TEM-1 towards resistance on the antibiotic… read more here.
Keywords: deleterious mutations; adaptive evolution; mistranslation; mistranslation enhance ... See more keywords
Visualizing tRNA-dependent mistranslation in human cells
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DOI: 10.1080/15476286.2017.1379645
Abstract: ABSTRACT High-fidelity translation and a strictly accurate proteome were originally assumed as essential to life and cellular viability. Yet recent studies in bacteria and eukaryotic model organisms suggest that proteome-wide mistranslation can provide selective advantages… read more here.
Keywords: dependent mistranslation; trna dependent; mistranslation; visualizing trna ... See more keywords
Proteogenomics analysis of CUG codon translation in the human pathogen Candida albicans
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DOI: 10.1186/s12915-021-01197-9
Abstract: Background Yeasts of the CTG-clade lineage, which includes the human-infecting Candida albicans , Candida parapsilosis and Candida tropicalis species, are characterized by an altered genetic code. Instead of translating CUG codons as leucine, as happens… read more here.
Keywords: cug codons; mistranslation; cug; trna ... See more keywords
Modulating Mistranslation Potential of tRNASer in Saccharomyces cerevisiae.
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DOI: 10.1534/genetics.119.302525
Abstract: Mistranslation, incorporating an amino acid not specified by the "standard" genetic code, has applications in research and synthetic biology. Since mistranslation is toxic, its level must be modulated. Using a serine tRNA with a proline… read more here.
Keywords: mistranslation potential; potential trnaser; biology; mistranslation ... See more keywords