NLX-112, a highly selective 5-HT1A receptor biased agonist, does not exhibit misuse potential in male rats or macaques
Sign Up to like & getrecommendations! Published in 2022 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2022.109025
Abstract: NLX-112 (a.k.a. F13640 or befiradol) exhibits nanomolar affinity, exceptional selectivity and biased agonism at serotonin 5-HT1A receptors. NLX-112 displays robust analgesic activity in a number of rodent models of pain, and is currently developed as… read more here.
Keywords: misuse potential; ht1a; nlx 112; icss ... See more keywords
Monitoring of drug misuse or potential misuse in a nationwide healthcare insurance database: A cross-sectional study in France.
Sign Up to like & getrecommendations! Published in 2018 at "Therapie"
DOI: 10.1016/j.therap.2018.12.007
Abstract: AIM OF THE STUDY To provide a tool for drug misuse or potential misuse monitoring by using a healthcare insurance database. METHODS A cross-sectional study repeated quarterly from 2007 to 2014 was conducted using data… read more here.
Keywords: misuse; study; drug; drug misuse ... See more keywords
Addressing the Misuse Potential of Life Science Research—Perspectives From a Bottom-Up Initiative in Switzerland
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2018.00038
Abstract: Codes of conduct have received wide attention as a bottom-up approach to foster responsibility for dual use aspects of life science research within the scientific community. In Switzerland, a series of discussion sessions led by… read more here.
Keywords: research; science research; life science; misuse potential ... See more keywords