Glucosamine abrogates the stem cell factor + endothelin-1-induced stimulation of melanogenesis via a deficiency in MITF expression due to the proteolytic degradation of CREB in human melanocytes
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Dermatological Research"
DOI: 10.1007/s00403-018-1850-8
Abstract: We have already reported that glucosamine (GlcN) distinctly abrogates the pigmentation of human epidermal equivalents stimulated by stem cell factor + endothelin-1 (SE). In this study, we characterized the molecular mechanism involved in the anti-melanogenic effects of… read more here.
Keywords: mitf; glcn; stimulation; creb ... See more keywords
Mitf is required for T cell maturation by regulating dendritic cell homing to the thymus.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.01.091
Abstract: Thymic dendritic cells (DCs) promote immune tolerance by regulating negative selection of autoreactive T cells in the thymus. How DC homing to the thymus is transcriptionally regulated is still unclear. Microphthalmia-associated transcription factor (Mitf) is… read more here.
Keywords: homing thymus; cell maturation; mitf required; required cell ... See more keywords
Anti-melanogenic activity of phytosphingosine via the modulation of the microphthalmia-associated transcription factor signaling pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2017.03.011
Abstract: BACKGROUND Microphthalmia-associated transcription factor (MITF) suppresses the expression of enzymes controlling the production of melanin. Phytosphingosine is a well-known cosmetic agent, but its anti-melanogenic activity and mechanism of action remain unclear. OBJECTIVE This study was… read more here.
Keywords: transcription; mitf; phytosphingosine; melanogenic activity ... See more keywords
STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway
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DOI: 10.1038/s41388-020-01584-6
Abstract: Metastatic melanoma is hallmarked by its ability of phenotype switching to more slowly proliferating, but highly invasive cells. Here, we tested the impact of signal transducer and activator of transcription 3 (STAT3) on melanoma progression… read more here.
Keywords: melanoma; transcription; mitf; stat3 promotes ... See more keywords
MITF variants cause nonsyndromic sensorineural hearing loss with autosomal recessive inheritance
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-69633-4
Abstract: MITF is a known gene underlying autosomal dominant hearing loss, Waardenburg syndrome (WS). Biallelic MITF mutations have been found associated with a rare hearing loss syndrome consisting eye abnormalities and albinism; and a more severe… read more here.
Keywords: hearing loss; mitf; gene; autosomal recessive ... See more keywords
PO-214 Conditional control of MITF reveals cellular subpopulations essential for melanoma survival and recurrence in new zebrafish models
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.732
Abstract: Introduction Melanoma is the most lethal type of skin cancer and its incidence continues to rise rapidly. While BRAFV600E inhibitors have led to significant improvements in outcomes for some patients, there are no targeted therapies… read more here.
Keywords: melanoma; mitf; regression; activity ... See more keywords
Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005699
Abstract: Background Microphthalmia-associated transcription factor (MITF) is a master regulator of melanogenesis and is mainly expressed in melanoma cells. MITF has also been reported to be expressed in non-pigmented cells, such as osteoclasts, mast cells, and… read more here.
Keywords: mitf; mdscs; differentiation; tumor ... See more keywords
Study on the Mechanism of miR-125b-5p Affecting Melanocyte Biological Behavior and Melanogenesis in Vitiligo through Regulation of MITF
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/6832680
Abstract: Objective The goal was to confirm the mechanism by which miR-125b-5p influences melanocyte biological behavior and melanogenesis in vitiligo by regulating MITF. Methods oe-MITF, sh-MITF, miR-125b-5p mimic, NC-mimic, NC-inhibitor, and miR-125b-5p inhibitor were transfected into… read more here.
Keywords: mitf; mir 125b; expression; group ... See more keywords
MITF-High and MITF-Low Cells and a Novel Subpopulation Expressing Genes of Both Cell States Contribute to Intra- and Intertumoral Heterogeneity of Primary Melanoma
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-17-0010
Abstract: Purpose: Understanding tumor heterogeneity is an important challenge in current cancer research. Transcription and epigenetic profiling of cultured melanoma cells have defined at least two distinct cell phenotypes characterized by distinctive gene expression signatures associated… read more here.
Keywords: mitf high; mitf; heterogeneity; gene expression ... See more keywords
Characterizing the Coding Region Determinant-Binding Protein (CRD-BP)-Microphthalmia-associated Transcription Factor (MITF) mRNA interaction
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DOI: 10.1371/journal.pone.0171196
Abstract: Coding region determinant-binding protein (CRD-BP) binds to the 3’-UTR of microphthalmia-associated transcription factor (MITF) mRNA to prevent its targeted degradation by miR-340. Here, we aim to further understand the molecular interaction between CRD-BP and MITF… read more here.
Keywords: crd; mitf; mitf rna; coding region ... See more keywords
MITF Is Regulated by Redox Signals Controlled by the Selenoprotein Thioredoxin Reductase 1
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14205011
Abstract: Simple Summary Melanomas and the melanocytes from which they arise are subject to the damaging effects of reactive oxygen species (ROS) from exogenous and endogenous sources. Many attempts have been made to counteract these effects… read more here.
Keywords: mitf; mitf regulated; thioredoxin reductase; regulated redox ... See more keywords