Active Ras2 in mitochondria promotes regulated cell death in a cAMP/PKA pathway‐dependent manner in budding yeast
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14567
Abstract: Previously, we showed that an aberrant accumulation of activated Ras in mitochondria correlates with an increase in apoptosis. In this article, we show that lack of trehalose‐6P‐synthase, known to trigger apoptosis in Saccharomyces cerevisiae, induces localization… read more here.
Keywords: active ras2; pka pathway; regulated cell; mitochondria ... See more keywords
Mitochondria‐Driven Dye Rearrangement That Enables Spatiotemporally Controlled Photomedicine
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201611
Abstract: Reversibly controlling the dye arrangements in living systems has great potential to realize spatiotemporally controlled photomedicine. However, tuning or even maintaining a certain arrangement of dyes in a complex living environments is extremely challenging due… read more here.
Keywords: controlled photomedicine; driven dye; dye rearrangement; mitochondria ... See more keywords
Incorporating a Polyethyleneglycol Linker to Enhance the Hydrophilicity of Mitochondria‐Targeted Triphenylphosphonium Constructs
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200774
Abstract: The targeting of bioactive molecules and probes to mitochondria can be achieved by coupling to the lipophilic triphenyl phosphonium (TPP) cation, which accumulates several hundred‐fold within mitochondria in response to the mitochondrial membrane potential (Δψm).… read more here.
Keywords: mitochondria targeted; linker; enhance; within mitochondria ... See more keywords
Invariance of Mitochondria and Synapses in the Primary Visual Cortex of Mammals Provides Insight Into Energetics and Function
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25669
Abstract: The cerebral cortex accounts for substantial energy expenditure, primarily driven by the metabolic demands of synaptic signaling. Mitochondria, the organelles responsible for generating cellular energy, play a crucial role in this process. We investigated ultrastructural… read more here.
Keywords: primary visual; invariance mitochondria; visual cortex; mitochondria ... See more keywords
Effects of axon branching and asymmetry between the branches on transport, mean age, and age density distributions of mitochondria in neurons: A computational study
Sign Up to like & getrecommendations! Published in 2022 at "International Journal for Numerical Methods in Biomedical Engineering"
DOI: 10.1002/cnm.3648
Abstract: We report a computational study of mitochondria transport in a branched axon with two branches of different sizes. For comparison, we also investigate mitochondria transport in an axon with symmetric branches and in a straight… read more here.
Keywords: computational study; mitochondria transport; age; mitochondria age ... See more keywords
Centrifugation‐Free Magnetic Isolation of Functional Mitochondria Using Paramagnetic Iron Oxide Nanoparticles
Sign Up to like & getrecommendations! Published in 2017 at "Current Protocols in Cell Biology"
DOI: 10.1002/cpcb.26
Abstract: Subcellular fractionation techniques are essential for cell biology and drug development studies. The emergence of organelle‐targeted nanoparticle (NP) platforms necessitates the isolation of target organelles to study drug delivery and activity. Mitochondria‐targeted NPs have attracted… read more here.
Keywords: iron oxide; mitochondria; biology; mitochondria using ... See more keywords
Nickel oxide nanoparticles exert selective toxicity on skin mitochondria and lysosomes isolated from the mouse model of melanoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22376
Abstract: Nickel oxide nanoparticles (NiO‐NPs) are progressively used for an immense number of new applications in modern industries sectors. Nevertheless, the toxic impact of NiO‐NPs has not been clearly elucidated on human melanoma cell lines at… read more here.
Keywords: melanoma; nio nps; oxide nanoparticles; mitochondria ... See more keywords
Glycyrrhetinic Acid Functionalized Graphene Oxide for Mitochondria Targeting and Cancer Treatment In Vivo.
Sign Up to like & getrecommendations! Published in 2018 at "Small"
DOI: 10.1002/smll.201703306
Abstract: Mitochondria-mediated apoptosis (MMA) is a preferential option for cancer therapy due to the presence of cell-suicide factors in mitochondria, however, low permeability of mitochondria is a bottleneck for targeting drug delivery. In this paper, glycyrrhetinic… read more here.
Keywords: graphene oxide; glycyrrhetinic acid; functionalized graphene; delivery ... See more keywords
Automated Optical Tweezers Manipulation to Transfer Mitochondria from Fetal to Adult MSCs to Improve Antiaging Gene Expressions.
Sign Up to like & getrecommendations! Published in 2021 at "Small"
DOI: 10.1002/smll.202103086
Abstract: Mitochondrial dysfunction is considered to be an important factor that leads to aging and premature aging diseases. Transferring mitochondria to cells is an emerging and promising technique for the therapy of mitochondrial deoxyribonucleic acid (mtDNA)-related… read more here.
Keywords: optical tweezers; automated optical; mitochondria; transfer ... See more keywords
A Less-is-More Strategy for Mitochondria-Targeted Photodynamic Therapy of Rheumatoid Arthritis.
Sign Up to like & getrecommendations! Published in 2024 at "Small"
DOI: 10.1002/smll.202307261
Abstract: Conventional photodynamic therapy (PDT) of rheumatoid arthritis (RA) faces a dilemma: low-power is insufficient to kill pro-inflammatory cells while high-power exacerbates inflammation. Herein, mitochondrial targeting is introduced in PDT of RA to implement a "less-is-more"… read more here.
Keywords: mitochondria; less strategy; pro inflammatory; power ... See more keywords
Bridging the Gap Between Nature and Antioxidant Setbacks: Delivering Gallic Acid to Mitochondria.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1262-0_10
Abstract: Research on mitochondria-targeted active molecules became a hot topic in the past decade. Development of mitochondria permeability transition pore (mPTP )-targeting agents with clinical applications is needed not only because of the importance of the… read more here.
Keywords: nature antioxidant; gallic acid; mitochondria; bridging gap ... See more keywords