Boosting ER-mitochondria calcium transfer to treat Wolfram syndrome.
Sign Up to like & getrecommendations! Published in 2022 at "Cell calcium"
DOI: 10.1016/j.ceca.2022.102572
Abstract: Wolfram syndrome is a rare genetic disorder characterized by endocrine dysfunction and progressive neurodegeneration. By targeting intracellular calcium dysregulations, a sigma-1 receptor agonist rescued neurological deficits in preclinical models of Wolfram syndrome. read more here.
Keywords: boosting mitochondria; wolfram syndrome; calcium; calcium transfer ... See more keywords
Mitochondria and Calcium Regulation as Basis of Neurodegeneration Associated With Aging
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2018.00470
Abstract: Age is the main risk factor for the onset of neurodegenerative diseases. A decline of mitochondrial function has been observed in several age-dependent neurodegenerative diseases and may be a major contributing factor in their progression.… read more here.
Keywords: mitochondria calcium; calcium regulation; neurodegenerative diseases; neurodegeneration ... See more keywords