Nanodrug Inducing Autophagy Inhibition and Mitochondria Dysfunction for Potentiating Tumor Photo-Immunotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202300280
Abstract: Anticancer immunotherapy is hampered by the poor tumor immunogenicity and immunosuppressive tumor microenvironment (TME). Herein, a liposome nanodrug co-encapsulating doxycycline hydrochloride (Doxy) and chlorin e6 (Ce6) to simultaneously induce autophagy inhibition and mitochondria dysfunction for… read more here.
Keywords: autophagy inhibition; immunotherapy; tumor; mitochondria dysfunction ... See more keywords
DDT exposure induces cell cycle arrest and apoptosis of skin fibroblasts from Indo-Pacific humpback dolphin via mitochondria dysfunction.
Sign Up to like & getrecommendations! Published in 2019 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2019.105229
Abstract: Although the global use of the 1,1,1-trichloro-2,2-bis (4-chlorophenyl) ethane (p,p'-DDT) has been prohibited, its persistence in the environment has caused long-lasting exposure on marine mammals. Our previous studies revealed exceedingly high residue levels of DDTs… read more here.
Keywords: ddt exposure; apoptosis; mitochondria dysfunction; humpback ... See more keywords
Nonylphenol exposure affects mouse oocyte quality by inducing spindle defects and mitochondria dysfunction.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental pollution"
DOI: 10.1016/j.envpol.2020.114967
Abstract: Nonylphenol (NP) is a chemical raw material and intermediate which is mainly used in the production of surfactants, lubricating oil additives and pesticide emulsifiers. NP is reported to be toxic on the immune system, nervous… read more here.
Keywords: mitochondria dysfunction; mouse oocyte; oocyte quality; exposure ... See more keywords
Loss of mpv17 affected early embryonic development via mitochondria dysfunction in zebrafish
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death Discovery"
DOI: 10.1038/s41420-021-00630-w
Abstract: MVP17 encodes a mitochondrial inner-membrane protein, and mutation of human MVP17 can cause mitochondria DNA depletion syndrome (MDDS). However, the underlying function of mpv17 is still elusive. Here, we developed a new mutant with mpv17… read more here.
Keywords: mitochondria dysfunction; mpv17 zebrafish; via mitochondria; mpv17 ... See more keywords
Mitochondria dysfunction in airway epithelial cells is associated with type 2-low asthma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1186317
Abstract: Background: Type 2 (T2)-low asthma can be severe and corticosteroid-resistant. Airway epithelial cells play a pivotal role in the development of asthma, and mitochondria dysfunction is involved in the pathogenesis of asthma. However, the role… read more here.
Keywords: airway epithelial; asthma; low asthma; degs ... See more keywords
Mitochondria dysfunction in circulating tumor cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.947479
Abstract: Circulating tumor cells (CTCs) represent a subset of heterogeneous cells, which, once released from a tumor site, have the potential to give rise to metastasis in secondary sites. Recent research focused on the attempt to… read more here.
Keywords: circulating tumor; dysfunction circulating; tumor cells; tumor ... See more keywords