Downregulation of HIGD1B induces mitochondria‐mediated apoptosis in gastric cancer cells by inactivating Akt and ERK pathways
Sign Up to like & getrecommendations! Published in 2024 at "Drug Development Research"
DOI: 10.1002/ddr.22221
Abstract: Gastric cancer (GC) is one of the most common malignancies worldwide. Hypoxia‐inducible domain (HIGD) family members (e.g., HIGD1A) have been linked to tumor progression. However, the role of HIGD1B (another HIGD family member) in GC… read more here.
Keywords: higd1b; mediated apoptosis; gastric cancer; higd1b levels ... See more keywords
Non-thermal plasma induces mitochondria-mediated apoptotic signaling pathway via ROS generation in HeLa cells.
Sign Up to like & getrecommendations! Published in 2017 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2017.09.005
Abstract: Non-thermal plasma (NTP) has been proposed as a novel therapeutic method for anticancer treatment. Although increasing evidence suggests that NTP selectively induces apoptosis in some types of tumor cells, the molecular mechanisms underlying this phenomenon… read more here.
Keywords: mitochondria mediated; ros generation; hela; ntp exposure ... See more keywords
NPD1 rapidly targets mitochondria-mediated apoptosis after acute injection protecting brain against ischemic injury
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113495
Abstract: Mitochondria-related cell death pathways play a major role in ischemic brain injury. Thus, mitochondrial "protective" molecules could be considered for new therapeutic regimens. We recently reported that acute administration of docosahexaenoic acid (DHA) triglyceride lipid… read more here.
Keywords: mitochondria mediated; ischemic injury; brain; mediated apoptosis ... See more keywords
Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.22618
Abstract: Colon cancer is the third most common malignancy worldwide, and chemotherapy is a widely used strategy in clinical therapy. Chemotherapy-resistant of colon cancer is the main cause of recurrence and progression. Novel drugs with efficacy… read more here.
Keywords: mitochondria mediated; apoptosis; colon; shikonin ... See more keywords
Mitochondria-mediated disturbance of fatty acid metabolism in proximal tubule epithelial cells leads to renal interstitial fibrosis.
Sign Up to like & getrecommendations! Published in 2018 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201811_16240
Abstract: The article "Mitochondria-mediated disturbance of fatty acid metabolism in proximal tubule epithelial cells leads to renal interstitial fibrosis" by W. Shen, X.-X. Jiang, Y.-W. Li, Q. He, published in Eur Rev Med Pharmacol Sci 2018;… read more here.
Keywords: disturbance fatty; mitochondria mediated; acid metabolism; mediated disturbance ... See more keywords
Exercise Training Attenuates Obesity-Induced Skeletal Muscle Remodeling and Mitochondria-Mediated Apoptosis in the Skeletal Muscle
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph15102301
Abstract: Obesity is characterized by the induction of skeletal muscle remodeling and mitochondria-mediated apoptosis. Exercise has been reported as a positive regulator of skeletal muscle remodeling and apoptosis. However, the effects of exercise on skeletal muscle… read more here.
Keywords: skeletal muscle; mitochondria mediated; apoptosis; muscle ... See more keywords
Thiazolidinedione-Conjugated Lupeol Derivatives as Potent Anticancer Agents Through a Mitochondria-Mediated Apoptotic Pathway
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DOI: 10.3390/molecules29204957
Abstract: To improve the potential of lupeol against cancer cells, a privileged structure, thiazolidinedione, was introduced into its C-3 hydroxy group with ester, piperazine-carbamate, or ethylenediamine as a linker, and three series of thiazolidinedione-conjugated compounds (6a–i,… read more here.
Keywords: cancer; thiazolidinedione conjugated; mediated apoptotic; apoptotic pathway ... See more keywords