A Mitochondria-Specific Fluorescent Probe for Visualizing Endogenous Hydrogen Cyanide Fluctuations in Neurons.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b12545
Abstract: An ability to visualize HCN in mitochondria in real time may permit additional insights into the critical toxicological and physiological roles this classic toxin plays in living organisms. Herein, we report a mitochondria-specific coumarin pyrrolidinium-derived… read more here.
Keywords: fluorescent probe; probe; hcn mitochondria; mitochondria specific ... See more keywords
A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac779
Abstract: Abstract The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the known mutational signatures of the nuclear genome and variation in mtDNA mutational spectra between different organisms is still incomprehensible. Since… read more here.
Keywords: mitochondria specific; heavy strand; substitutions heavy; generation ... See more keywords
Reactive oxygen species activated by mitochondria-specific camptothecin prodrug for enhanced chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Bosnian Journal of Basic Medical Sciences"
DOI: 10.17305/bjbms.2022.7194
Abstract: Camptothecin (CPT) has attracted much attention due to its potent antitumor activities. However, the undesirable physicochemical properties, including poor water solubility, unstable lactone ring, and severe adverse effects, limit its further application. In this study,… read more here.
Keywords: reactive oxygen; activated mitochondria; mitochondria specific; oxygen species ... See more keywords