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   Articles with "mitochondria specific" as a keyword



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A Mitochondria-Specific Fluorescent Probe for Visualizing Endogenous Hydrogen Cyanide Fluctuations in Neurons.

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recommendations! Published in 2018 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.7b12545

Abstract: An ability to visualize HCN in mitochondria in real time may permit additional insights into the critical toxicological and physiological roles this classic toxin plays in living organisms. Herein, we report a mitochondria-specific coumarin pyrrolidinium-derived… read more here.

Keywords: fluorescent probe; probe; hcn mitochondria; mitochondria specific ... See more keywords

A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac779

Abstract: Abstract The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the known mutational signatures of the nuclear genome and variation in mtDNA mutational spectra between different organisms is still incomprehensible. Since… read more here.

Keywords: mitochondria specific; heavy strand; substitutions heavy; generation ... See more keywords

Reactive oxygen species activated by mitochondria-specific camptothecin prodrug for enhanced chemotherapy

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recommendations! Published in 2022 at "Bosnian Journal of Basic Medical Sciences"

DOI: 10.17305/bjbms.2022.7194

Abstract: Camptothecin (CPT) has attracted much attention due to its potent antitumor activities. However, the undesirable physicochemical properties, including poor water solubility, unstable lactone ring, and severe adverse effects, limit its further application. In this study,… read more here.

Keywords: reactive oxygen; activated mitochondria; mitochondria specific; oxygen species ... See more keywords

Mitochondria-specific targeting of noncanonical EGR1 ntmRNA-coordinated mitophagy receptor BNIP3 homodimerization disrupts mitochondrial metabolism and suppresses hepatocellular carcinoma growth in vitro and in vivo.

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recommendations! Published in 2026 at "Theranostics"

DOI: 10.7150/thno.117745

Abstract: Background: Hypoxia-driven metabolic reprogramming is a hallmark of hepatocellular carcinoma (HCC) and depends critically on mitochondrial signaling. We sought to identify RNA-based molecular factors that orchestrate the hypoxia-mitochondria crosstalk and regulate metabolic adaptation in HCC… read more here.

Keywords: egr1 ntmrna; mitochondria specific; hepatocellular carcinoma; egr1 ... See more keywords