Incorporating a Polyethyleneglycol Linker to Enhance the Hydrophilicity of Mitochondria‐Targeted Triphenylphosphonium Constructs
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200774
Abstract: The targeting of bioactive molecules and probes to mitochondria can be achieved by coupling to the lipophilic triphenyl phosphonium (TPP) cation, which accumulates several hundred‐fold within mitochondria in response to the mitochondrial membrane potential (Δψm).… read more here.
Keywords: mitochondria targeted; linker; enhance; within mitochondria ... See more keywords
Mitochondria‐Targeted Antioxidants and Uncouplers of Oxidative Phosphorylation in Treatment of the Systemic Inflammatory Response Syndrome (SIRS)
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DOI: 10.1002/jcp.25626
Abstract: Systemic inflammatory response syndrome (SIRS) development is accompanied by mitochondrial dysfunction and excessive ROS production. Mitochondrial dysfunctions also occur in many SIRS‐related diseases and may be critical for their pathogenesis; therefore, a use of mitochondria‐targeted… read more here.
Keywords: mitochondria targeted; uncouplers oxidative; inflammatory response; systemic inflammatory ... See more keywords
Mitochondria-Targeted Agents: Mitochondriotropics, Mitochondriotoxics, and Mitocans.
Sign Up to like & getrecommendations! Published in 2017 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2016_37
Abstract: Mitochondria, the powerhouse of the cell, have been known for many years for their central role in the energy metabolism; however, extensive progress has been made and to date substantial evidence demonstrates that mitochondria play… read more here.
Keywords: mitochondria targeted; agents mitochondriotropics; mitochondriotropics mitochondriotoxics; mitochondriotoxics mitocans ... See more keywords
Mitochondria-Targeted Antioxidants for the Treatment of Cardiovascular Disorders.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-55330-6_32
Abstract: The heart continuously supplies blood to the entire body throughout the lifetime, requiring a huge amount of the bioenergy molecule adenosine triphosphate (ATP). As the major subcellular organs that produce ATP through oxidative phosphorylation and… read more here.
Keywords: mitochondria targeted; targeted antioxidants; biology; treatment cardiovascular ... See more keywords
A mitochondria-targeted single fluorescence probe for separately and continuously visualizing H2S and Cys with multi-response signals.
Sign Up to like & getrecommendations! Published in 2020 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2020.02.017
Abstract: Hydrogen sulfide and cysteine are momentous endogenous regulators of many physiological processes and maintain a dynamic balance of redox in living organisms. To investigate the inter-relationship of them in vivo, there is a pressing need to… read more here.
Keywords: mitochondria targeted; h2s cys; fluorescence; targeted single ... See more keywords
Triphenylphosphonium-modified mitochondria-targeted paclitaxel nanocrystals for overcoming multidrug resistance
Sign Up to like & getrecommendations! Published in 2019 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2018.06.006
Abstract: Mitochondria are currently known as novel targets for treating cancer, especially for tumors displaying multidrug resistance (MDR). This present study aimed to develop a mitochondria-targeted delivery system by using triphenylphosphonium cation (TPP+)-conjugated Brij 98 as… read more here.
Keywords: targeted ptx; mitochondria targeted; mcf; mcf adr ... See more keywords
Effects of freezing extender supplementation with mitochondria-targeted antioxidant Mito-TEMPO on frozen-thawed rooster semen quality and reproductive performance.
Sign Up to like & getrecommendations! Published in 2020 at "Animal reproduction science"
DOI: 10.1016/j.anireprosci.2020.106671
Abstract: Rooster semen cryopreservation is a useful method to utilize semen samples for artificial insemination in commercial flocks, but with use of the freezing-thawing process there is a reduction in the quality and fertilization capacity of… read more here.
Keywords: mitochondria targeted; rooster semen; mito; mito tempo ... See more keywords
A pH-Activatable nanoparticle for dual-stage precisely mitochondria-targeted photodynamic anticancer therapy.
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DOI: 10.1016/j.biomaterials.2019.05.030
Abstract: Mitochondria-targeted photodynamic therapy (PDT) has emerged as one of the most efficient antitumor strategies. However, the therapeutic outcome of mitochondria-targeted PDT nanocarriers has been hampered by its poor capability of endosome escape and always-ON mode… read more here.
Keywords: dual stage; mitochondria targeted; targeted photodynamic; activatable nanoparticle ... See more keywords
Mitochondria-targeted ratiometric fluorescent probes for micropolarity and microviscosity and their applications
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DOI: 10.1016/j.cclet.2018.12.031
Abstract: Abstract Two fluorescent “off-on” probes YYH1 and YYH2 were used for the detection of mitochondrial polarity and viscosity. Both probes have two emission bands: The peak of shorter wavelength was sensitive to the polarity, while… read more here.
Keywords: polarity viscosity; viscosity; mitochondria targeted; fluorescent probes ... See more keywords
BODIPY-based fluorescent probes for mitochondria-targeted cell imaging with superior brightness, low cytotoxicity and high photostability
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DOI: 10.1016/j.dyepig.2017.03.009
Abstract: Abstract Two mitochondria-targeted fluorescent probes (TPP- and TEA-BODIPY) were rationally designed and easily synthesized. These probes can specifically stain mitochondria in living cells with superior brightness, low cytotoxicity and high photostability, thus are quite promising… read more here.
Keywords: mitochondria targeted; cytotoxicity high; low cytotoxicity; brightness low ... See more keywords
Mito‐TEMPO, a mitochondria‐targeted antioxidant, prevents N‐nitrosodiethylamine‐induced hepatocarcinogenesis in mice
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2019.03.037
Abstract: Background: Oxidative stress and mitochondrial dysfunction play a significant role in hepatocarcinogenesis. Mitochondria are source organelle as well as target for free radicals. The oxidative damage to mitochondria can be prevented by mitochondria‐targeted antioxidant, mito‐TEMPO.… read more here.
Keywords: mitochondria targeted; mito tempo; hepatocarcinogenesis; targeted antioxidant ... See more keywords