Glycyrrhetinic Acid Functionalized Graphene Oxide for Mitochondria Targeting and Cancer Treatment In Vivo.
Sign Up to like & getrecommendations! Published in 2018 at "Small"
DOI: 10.1002/smll.201703306
Abstract: Mitochondria-mediated apoptosis (MMA) is a preferential option for cancer therapy due to the presence of cell-suicide factors in mitochondria, however, low permeability of mitochondria is a bottleneck for targeting drug delivery. In this paper, glycyrrhetinic… read more here.
Keywords: graphene oxide; glycyrrhetinic acid; functionalized graphene; delivery ... See more keywords
Mitochondria-targeting supra-carbon dots: Enhanced photothermal therapy selective to cancer cells and their hyperthermia molecular actions
Sign Up to like & getrecommendations! Published in 2020 at "Carbon"
DOI: 10.1016/j.carbon.2019.09.079
Abstract: Abstract Carbon dots (CDs) have been widely used in biological research including bioimaging, biosensing, and biomedicine because of their excellent biocompatibility. However, inefficient absorption of these CDs in the visible-to-near-infrared window limits their applications for… read more here.
Keywords: carbon dots; cancer cells; cancer; supra carbon ... See more keywords
A novel mitochondria-targeting tetrapeptide for subcellular delivery of nanoparticles
Sign Up to like & getrecommendations! Published in 2019 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2019.05.001
Abstract: Abstract Mitochondrial dysfunction is associated with the emergence of several neurological and cardiovascular diseases. Hence, mitochondria-targeting delivery strategies are highly significant and critically needed. In this study, we developed a small library of peptides simulating… read more here.
Keywords: targeting tetrapeptide; delivery nanoparticles; novel mitochondria; tetrapeptide subcellular ... See more keywords
A mitochondria-targeting fluorescent Fe3+ probe and its application in labile Fe3+ monitoring via imaging and flow cytometry
Sign Up to like & getrecommendations! Published in 2018 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2018.05.008
Abstract: Abstract The biogenesis of heme and iron-sulfur cluster in mitochondria is closely associated with the intracellular iron homeostasis. In this study, a mitochondria-targeting probe with the reversible turn-on fluorescent response to Fe3+ was developed for… read more here.
Keywords: labile fe3; probe; fe3 monitoring; imaging flow ... See more keywords
Mitochondria-targeting BODIPY-loaded micelles as novel class of photosensitizer for photodynamic therapy.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.08.024
Abstract: In this paper, a series of novel BODIPY-based photosensitizers have been designed and synthesized for photodynamic therapy. BODIPY3 was screened out as the most potential photosensitizer due to its excellent optical properties, high singlet oxygen… read more here.
Keywords: photodynamic therapy; bodipy3 peg3; therapy; mitochondria targeting ... See more keywords
Mitochondria-targeting hydrogen sulfide donors prolong healthspan: lifespan ratio in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.067
Abstract: Progressive muscle atrophy is characteristic of several chronic debilitating conditions, including ageing (sarcopenia), muscular dystrophies, diabetes, bedrest and spaceflight. Whilst the precise mechanisms of slow atrophy are poorly defined and multifactorial, impaired mitochondrial ‘function’ (e.g.… read more here.
Keywords: hydrogen sulfide; healthspan lifespan; mitochondria targeting; caenorhabditis elegans ... See more keywords
Mitochondria-targeting peptides and peptidomimetics: recent progress and design principles.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00857
Abstract: Mitochondria are multifunctional subcellular organelles whose operations encompass energy production, signal transduction, and metabolic regulation. Given their wide range of roles, they have been studied extensively as a potential therapeutic target for the treatment of… read more here.
Keywords: peptides peptidomimetics; peptidomimetics recent; recent progress; targeting peptides ... See more keywords
Bioreducible Poly(ethylene glycol)-Triphenylphosphonium Conjugate as a Bioactivable Mitochondria-Targeting Nanocarrier.
Sign Up to like & getrecommendations! Published in 2017 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.6b01324
Abstract: Bioactivable nanocarrier systems have favorable characteristics such as high cellular uptake, target specificity, and an efficient intracellular release mechanism. In this study, we developed a bioreducible methoxy polyethylene glycol (mPEG)-triphenylphosphonium (TPP) conjugate (i.e., mPEG-(ss-TPP)2 conjugate)… read more here.
Keywords: mpeg tpp; conjugate; triphenylphosphonium; mitochondria targeting ... See more keywords
Mitochondria-Targeting Pyroptosis Amplifier of Lonidamine-Modified Black Phosphorus Nanosheets for Glioblastoma Treatments.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.3c01559
Abstract: Pyroptosis is accompanied by immunogenic mediators' release and serves as an innovative strategy to reprogram tumor microenvironments. However, damaged mitochondria, the origin of pyroptosis, are frequently eliminated by mitophagy, which will severely impair pyroptosis-elicited immune… read more here.
Keywords: bptld; pyroptosis; mitochondria targeting; black phosphorus ... See more keywords
Versatile Strategy To Generate a Rhodamine Triplet State as Mitochondria-Targeting Visible-Light Photosensitizers for Efficient Photodynamic Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b20224
Abstract: Through the use of a rhodamine-appended chelate, bpy-Rho, a versatile strategy has been demonstrated to readily form mitochondria-targeting photosensitizers via the incorporation of a variety of luminescent transition-metal systems, M-Rho, such as Re(I), Ir(III), Pt(II),… read more here.
Keywords: state; excited state; triplet; versatile strategy ... See more keywords
Water-Soluble Au25 Clusters with Single-Crystal Structure for Mitochondria-Targeting Radioimmunotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.3c01068
Abstract: Atomically precise gold clusters play an important role in the development of high-Z-element-based radiosensitizers, due to their intriguing structural diversity and advantages in correlating structures and properties. However, the synthesis of gold clusters with both… read more here.
Keywords: au25 clusters; single crystal; water; mitochondria targeting ... See more keywords