ER-mitochondria tethering and Ca2+ crosstalk: The IP3R team takes the field.
Sign Up to like & getrecommendations! Published in 2019 at "Cell calcium"
DOI: 10.1016/j.ceca.2019.102101
Abstract: Inter-organelle communication represents a booming topic in cell biology research, with endoplasmic reticulum (ER)-mitochondria coupling playing the lion's share. In a recent work, Bartok and colleagues found that inositol trisphosphates receptors (IP3Rs), in addition to… read more here.
Keywords: ca2 crosstalk; mitochondria; mitochondria tethering; tethering ca2 ... See more keywords
The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2016.12.038
Abstract: Summary Mitochondria form close physical associations with the endoplasmic reticulum (ER) that regulate a number of physiological functions. One mechanism by which regions of ER are recruited to mitochondria involves binding of the ER protein… read more here.
Keywords: autophagy mitochondria; ptpip51; mitochondria tethering; vapb ptpip51 ... See more keywords
Enhanced Mitochondria-SR Tethering Triggers Adaptive Cardiac Muscle Remodeling
Sign Up to like & getrecommendations! Published in 2023 at "Circulation Research"
DOI: 10.1161/circresaha.122.321833
Abstract: Background: Cardiac contractile function requires high energy from mitochondria, and Ca2+ from the sarcoplasmic reticulum (SR). Via local Ca2+ transfer at close mitochondria-SR contacts, cardiac excitation feedforward regulates mitochondrial ATP production to match surges in… read more here.
Keywords: cardiac muscle; bioenergetics coupling; excitation bioenergetics; mitochondria tethering ... See more keywords