Slingshot homolog-1 amplifies mitochondrial abnormalities by distinctly impairing health and clearance of mitochondria.
Sign Up to like & getrecommendations! Published in 2023 at "Human molecular genetics"
DOI: 10.1093/hmg/ddad006
Abstract: Accumulating toxic protein assemblies, including Aβ and tau, and dysfunctional mitochondria are associated with synaptic and neuronal loss in Alzheimer's disease (ad). Such accumulations are thought to be due to clearance defects in the autophagy-lysosome… read more here.
Keywords: clearance; health; terminal region; slingshot homolog ... See more keywords
Hippocampal Mitochondrial Abnormalities Induced the Dendritic Complexity Reduction and Cognitive Decline in a Rat Model of Spinal Cord Injury
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/9253916
Abstract: Spinal cord injury (SCI) is a progressive neurodegenerative disease in addition to a traumatic event. Cognitive dysfunction following SCI has been widely reported in patients and animal models. However, the neuroanatomical changes affecting cognitive function… read more here.
Keywords: cord injury; induced dendritic; dendritic complexity; mitochondrial abnormalities ... See more keywords
Mitochondrial abnormalities related to the dysfunction of circulating endothelial colony-forming cells in moyamoya disease.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of neurosurgery"
DOI: 10.3171/2017.5.jns17147
Abstract: The authors performed morphological and functional studies of the mitochondria in particular blood cells, i.e., endothelial colony-forming cells (ECFCs), from patients with moyamoya disease. The results indicated that the mitochondria of these ECFCs exhibit morphological… read more here.
Keywords: colony forming; forming cells; endothelial colony; mitochondrial abnormalities ... See more keywords
Common methods in mitochondrial research (Review)
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2022.5182
Abstract: Mitochondrial abnormalities are primarily seen in morphology, structure and function. They can cause damage to organs, including the heart, brain and muscle, by various mechanisms, such as oxidative stress, abnormal energy metabolism, or genetic mutations.… read more here.
Keywords: common methods; mitochondrial research; methods mitochondrial; mitochondrial abnormalities ... See more keywords
Mitochondrial proteomics reveal potential targets involved in mitochondrial abnormalities of desminopathy.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical neuropathology"
DOI: 10.5414/np300969
Abstract: AIMS To investigate the underlying mechanisms of how the defects of desmin cause mitochondrial abnormalities in desminopathy. MATERIAL AND METHODS Primary myoblasts were isolated from muscle biopsy of a desminopathy patient with mitochondrial abnormalities. Two-dimensional… read more here.
Keywords: mitochondrial proteomics; involved mitochondrial; potential targets; targets involved ... See more keywords