Calcium‐regulated mitochondrial ATP‐Mg/Pi carriers evolved from a fusion of an EF‐hand regulatory domain with a mitochondrial ADP/ATP carrier‐like domain
Sign Up to like & getrecommendations! Published in 2018 at "Iubmb Life"
DOI: 10.1002/iub.1931
Abstract: The mitochondrial ATP‐Mg/Pi carrier is responsible for the calcium‐dependent regulation of adenosine nucleotide concentrations in the mitochondrial matrix, which allows mitochondria to respond to changing energy requirements of the cell. The carrier is expressed in… read more here.
Keywords: atp carrier; mitochondrial adp; carrier; calcium ... See more keywords
Investigation of Mitochondrial ADP-Ribosylation Via Immunofluorescence.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1266-8_12
Abstract: ADP-ribosylation is a posttranslational protein modification, involved in various cellular processes, ranging from DNA-damage repair to apoptosis. While its function has been studied amply with respect to genotoxic stress-associated nuclear ADP-ribosylation, the functional relevance of… read more here.
Keywords: ribosylation via; mitochondrial adp; adp ribosylation; ribosylation ... See more keywords
Mitochondrial ADP/ATP Carrier in Dodecylphosphocholine Binds Cardiolipins with Non-native Affinity
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2017.09.019
Abstract: Biophysical investigation of membrane proteins generally requires their extraction from native sources using detergents, a step that can lead, possibly irreversibly, to protein denaturation. The propensity of dodecylphosphocholine (DPC), a detergent widely utilized in NMR… read more here.
Keywords: atp carrier; mitochondrial adp; dpc; adp atp ... See more keywords
The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier
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DOI: 10.1016/j.cell.2018.11.025
Abstract: Summary Mitochondrial ADP/ATP carriers transport ADP into the mitochondrial matrix for ATP synthesis, and ATP out to fuel the cell, by cycling between cytoplasmic-open and matrix-open states. The structure of the cytoplasmic-open state is known,… read more here.
Keywords: mitochondrial adp; adp atp; carrier; mechanism ... See more keywords
Epoxycyclohexenedione-Type Compounds Make Up a New Class of Inhibitors of the Bovine Mitochondrial ADP/ATP Carrier.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b01119
Abstract: Through the extensive screening of our chemical library, we found epoxycyclohexenedione (ECHD)-type compounds (AMM-59 and -120) as unique inhibitors of the bovine heart mitochondrial ADP/ATP carrier (AAC). This study investigated the mechanism of inhibition of… read more here.
Keywords: aggregation; atp carrier; mitochondrial adp; inhibitors bovine ... See more keywords
Reversible modification of mitochondrial ADP/ATP translocases by paired Legionella effector proteins
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122872119
Abstract: Significance Mitochondria are organelles of the central metabolism that produce ATP and play fundamental roles in eukaryotic cell function and thereby become targets for pathogenic bacteria to manipulate. We found that the intracellular bacterial pathogen,… read more here.
Keywords: effector proteins; mitochondrial adp; atp translocases; adp atp ... See more keywords