515-P: Mitochondrial AKT1 in Renal Tubules Is a Novel Modulator for the Development of Glomerulosclerosis and Subsequent Renal Failure
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DOI: 10.2337/db19-515-p
Abstract: Diabetes increases the risk of renal ischemia/reperfusion injury (IRI). Recent evidence suggests that tubular dysfunction is associated with glomerular impairment, but its causal relationship is unclear. Renal tubules have abundant mitochondria; Akt is translocated into… read more here.
Keywords: mitochondrial akt1; none; renal failure; subsequent renal ... See more keywords
1888-P: Activation of Myocardial Mitochondrial Akt1 Remotely Modulated Body Composition and Adiposity through LXR/RXR Signaling
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DOI: 10.2337/db20-1888-p
Abstract: Insulin resistance contributed to the development of type 2 diabetes (T2D) and is a major risk factor for diabetic cardiomyopathy (DCM). We have previously reported that insulin resistance led to impaired Akt1 translocation into myocardial… read more here.
Keywords: activation myocardial; mitochondrial akt1; 1888 activation; akt1 ... See more keywords