Computational Investigation of Structural Basis for Enhanced Binding of Isoflavone Analogues with Mitochondrial Aldehyde Dehydrogenase
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DOI: 10.1021/acsomega.2c00032
Abstract: Isoflavone compounds are potent inhibitors against mitochondrial aldehyde dehydrogenase (ALDH2) for the treatment of alcoholism and drug addiction, and an in-depth understanding of the underlying structural basis helps design new inhibitors for enhanced binding. Here,… read more here.
Keywords: aldehyde dehydrogenase; enhanced binding; mitochondrial aldehyde; structural basis ... See more keywords
Impact of mitochondrial aldehyde dehydrogenase 2 on cognitive impairment in the AD model mouse.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmab057
Abstract: Alzheimer's disease (AD) is one of the major life-threatening diseases for the elderly because neither pathogenesis nor effective treatment is available. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) has been shown to reduce the cell-damaging aldehydes in… read more here.
Keywords: aldehyde dehydrogenase; mitochondrial aldehyde; geometry; cell ... See more keywords