Mitohormesis in Mice via Sustained Basal Activation of Mitochondrial and Antioxidant Signaling.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.07.011
Abstract: Transient mitochondrial stress can promote beneficial physiological responses and longevity, termed "mitohormesis." To interrogate mitohormetic pathways in mammals, we generated mice in which mitochondrial superoxide dismutase 2 (SOD2) can be knocked down in an inducible… read more here.
Keywords: mitochondrial antioxidant; mitohormesis; activation mitochondrial; antioxidant signaling ... See more keywords
Effects of Altering Mitochondrial Antioxidant Capacity on Molecular and Phenotypic Drivers of Fibrocalcific Aortic Valve Stenosis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2021.694881
Abstract: Background: While a small number of studies suggest that oxidative stress has an influential role in fibrocalcific aortic valve disease (FCAVD), the roles of specific antioxidant enzymes in progression of this disease remain poorly understood.… read more here.
Keywords: antioxidant capacity; mitochondrial antioxidant; altering mitochondrial; phenotypic ... See more keywords
Inhibition of Mitochondrial Antioxidant Defense and CDK4/6 in Mesothelioma
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28114380
Abstract: Advanced mesothelioma is considered an incurable disease and new treatment strategies are needed. Previous studies have demonstrated that mitochondrial antioxidant defense proteins and the cell cycle may contribute to mesothelioma growth, and that the inhibition… read more here.
Keywords: antioxidant defense; mitochondrial antioxidant; inhibition; mesothelioma ... See more keywords