Current understanding of structure, function and biogenesis of yeast mitochondrial ATP synthase
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-019-09809-4
Abstract: The yeast mitochondrial ATP synthase is a rotary molecular machine primarily responsible for the production of energy used to drive cellular processes. The enzyme complex is composed of 17 different subunits grouped into a soluble… read more here.
Keywords: atp synthase; synthase; mitochondrial atp; yeast mitochondrial ... See more keywords
Structural and functional properties of plant mitochondrial F-ATP synthase.
Sign Up to like & getrecommendations! Published in 2020 at "Mitochondrion"
DOI: 10.1016/j.mito.2020.06.001
Abstract: The mitochondrial F-ATP synthase is responsible for coupling the transmembrane proton gradient, generated through the inner membrane by the electron transport chain, to the synthesis of ATP. This enzyme shares a basic architecture with the… read more here.
Keywords: atp synthase; plant; synthase; mitochondrial atp ... See more keywords
Bedaquiline inhibits the yeast and human mitochondrial ATP synthases
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-01173-z
Abstract: Bedaquiline (BDQ, Sirturo) has been approved to treat multidrug resistant forms of Mycobacterium tuberculosis. Prior studies suggested that BDQ was a selective inhibitor of the ATP synthase from M. tuberculosis. However, Sirturo treatment leads to… read more here.
Keywords: human mitochondrial; mitochondrial atp; bdq; atp synthases ... See more keywords
BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25433
Abstract: Cancer cells display differences regarding their engagement of glycolytic vs. mitochondrial oxidative phosphorylation (OXPHOS) pathway. Triple negative breast cancer, an aggressive form of breast cancer, is characterized by elevated glycolysis, while estrogen receptor positive breast… read more here.
Keywords: cancer; cancer cells; mitochondrial atp; breast cancer ... See more keywords
PHB3 Is Required for the Assembly and Activity of Mitochondrial ATP Synthase in Arabidopsis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24108787
Abstract: Mitochondrial ATP synthase is a multiprotein complex, which consists of a matrix-localized F1 domain (F1-ATPase) and an inner membrane-embedded Fo domain (Fo-ATPase). The assembly process of mitochondrial ATP synthase is complex and requires the function… read more here.
Keywords: phb3; synthase; atp synthase; atpase ... See more keywords