Mitochondrial uncoupling prodrug improves tissue sparing, cognitive outcome, and mitochondrial bioenergetics after traumatic brain injury in male mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24271
Abstract: Traumatic brain injury (TBI) results in cognitive impairment, which can be long‐lasting after moderate to severe TBI. Currently, there are no FDA‐approved therapeutics to treat the devastating consequences of TBI and improve recovery. This study… read more here.
Keywords: mitochondrial bioenergetics; traumatic brain; cognitive outcome; post injury ... See more keywords
Dihydroartemisinin, an active metabolite of artemisinin, interferes with Leishmania braziliensis mitochondrial bioenergetics and survival.
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology research"
DOI: 10.1007/s00436-020-07019-1
Abstract: Leishmaniasis is one of the most neglected parasitic infections of the world and current therapeutic options show several limitations. In the search for more effective drugs, plant compounds represent a powerful natural source. Artemisinin is… read more here.
Keywords: leishmania braziliensis; mitochondrial bioenergetics; dqhs; artemisinin ... See more keywords
Sea lamprey cardiac mitochondrial bioenergetics after exposure to TFM and its metabolites.
Sign Up to like & getrecommendations! Published in 2019 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2019.105380
Abstract: Population control of invasive sea lamprey relies heavily on lampricide treatment of infested streams. The lampricide 3-trifluoromethyl-4-nitrophenol (TFM) is thought to impair mitochondrial ATP production through uncoupling oxidative phosphorylation. However, the effect of TFM on… read more here.
Keywords: tfm; mitochondrial bioenergetics; sea lamprey; lamprey cardiac ... See more keywords
Cyclin B1/CDK1-regulated mitochondrial bioenergetics in cell cycle progression and tumor resistance.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.11.019
Abstract: A mammalian cell houses two genomes located separately in the nucleus and mitochondria. During evolution, communications and adaptations between these two genomes occur extensively to achieve and sustain homeostasis for cellular functions and regeneration. Mitochondria… read more here.
Keywords: cdk1; mitochondrial bioenergetics; cyclin cdk1; cell cycle ... See more keywords
Metabolite regulation of the mitochondrial calcium uniporter channel.
Sign Up to like & getrecommendations! Published in 2020 at "Cell calcium"
DOI: 10.1016/j.ceca.2020.102288
Abstract: Calcium (Ca2+) is known to stimulate mitochondrial bioenergetics through the modulation of TCA cycle dehydrogenases and electron transport chain (ETC) complexes. This is hypothesized to be an essential pathway of energetic control to meet cellular… read more here.
Keywords: mitochondrial bioenergetics; uniporter channel; calcium uniporter; mitochondrial calcium ... See more keywords
Quercetin, a natural product supplement, impairs mitochondrial bioenergetics and locomotor behavior in larval zebrafish (Danio rerio)
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.04.024
Abstract: ABSTRACT Quercetin is a natural product that is sold as a supplement in health food stores. While there are reported benefits for this flavonoid as a dietary supplement due to antioxidant properties, the full scope… read more here.
Keywords: mgr quercetin; mitochondrial bioenergetics; natural product; quercetin ... See more keywords
Investigating mitochondrial bioenergetics in peripheral blood mononuclear cells of women with childhood maltreatment from post-parturition period to one-year follow-up.
Sign Up to like & getrecommendations! Published in 2022 at "Psychological medicine"
DOI: 10.1017/s0033291722000411
Abstract: BACKGROUND Childhood maltreatment (CM) exerts various long-lasting psychological and biological changes in affected individuals, with inflammation being an interconnecting element. Besides chronic low-grade inflammation, CM might also affect the energy production of cells by altering… read more here.
Keywords: childhood maltreatment; density; mitochondrial bioenergetics; blood mononuclear ... See more keywords
NDUFAB1 confers cardio-protection by enhancing mitochondrial bioenergetics through coordination of respiratory complex and supercomplex assembly
Sign Up to like & getrecommendations! Published in 2019 at "Cell Research"
DOI: 10.1038/s41422-019-0208-x
Abstract: The impairment of mitochondrial bioenergetics, often coupled with exaggerated reactive oxygen species (ROS) production, is a fundamental disease mechanism in organs with a high demand for energy, including the heart. Building a more robust and… read more here.
Keywords: mitochondrial bioenergetics; heart; ndufab1 confers; cardio protection ... See more keywords
Valproate inhibits mitochondrial bioenergetics and increases glycolysis in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-68725-5
Abstract: The widely used mood stabilizer valproate (VPA) causes perturbation of energy metabolism, which is implicated in both the therapeutic mechanism of action of the drug as well as drug toxicity. To gain insight into these… read more here.
Keywords: mitochondrial bioenergetics; glycolysis; inhibits mitochondrial; increases glycolysis ... See more keywords
Pyraclostrobin Impairs Energetic Mitochondrial Metabolism and Productive Performance of Silkworm (Lepidoptera: Bombycidae) Caterpillars
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Economic Entomology"
DOI: 10.1093/jee/toy060
Abstract: Abstract Silkworm cocoon production has been reduced due to a number of problems other than those inherent in sericulture, such as diseases, malnutrition, and inappropriate management. The use of pesticides in areas surrounding mulberry fields… read more here.
Keywords: silkworm; productive performance; mitochondrial bioenergetics; impairs energetic ... See more keywords
RAGE availability lessens the degree of dysfunctional mitochondrial bioenergetics following chronic secondhand smoke exposure
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733415
Abstract: The receptor for advanced glycation end products (RAGE) is an immunoglobulin-type receptor abundantly expressed by lung parenchyma that coordinates inflammatory responses. We have previously described roles for RAGE following exposure to tobacco smoke (both primary… read more here.
Keywords: following chronic; mitochondrial bioenergetics; secondhand smoke; rage ... See more keywords