Quantitative analysis of mitochondrial calcium uniporter (MCU) and essential MCU regulator (EMRE) in mitochondria from mouse tissues and HeLa cells
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13371
Abstract: Mitochondrial calcium homeostasis plays critical roles in cell survival and aerobic metabolism in eukaryotes. The calcium uniporter is a highly selective calcium ion channel consisting of several subunits. Mitochondrial calcium uniporter (MCU) and essential MCU… read more here.
Keywords: mcu; calcium uniporter; mcu emre; emre ... See more keywords
Mitochondrial Calcium ion Nanogluttons Alleviate Periodontitis Via Controlling mPTPs.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202203106
Abstract: The mitochondrial permeability transition (mPT) directly affects mitochondrial function in macrophages. Under inflammatory conditions, mitochondrial calcium ion (mitoCa2+ ) overload triggers the persistent opening of mPT pores (mPTPs), further aggravating Ca2+ overload and increasing reactive… read more here.
Keywords: calcium ion; periodontitis; mitochondrial calcium; overload ... See more keywords
The mitochondrial calcium uniporter complex in trypanosomes
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DOI: 10.1002/cbin.10928
Abstract: The presence of a conserved mechanism for mitochondrial calcium uptake in trypanosomatids was crucial for the molecular identification of the mitochondrial calcium uniporter (MCU), a long‐sought channel present in most eukaryotic organisms. Since then, research… read more here.
Keywords: calcium uniporter; complex trypanosomes; uniporter complex; mitochondrial calcium ... See more keywords
Structure-Activity Relationships of Metal-Based Inhibitors of the Mitochondrial Calcium Uniporter.
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DOI: 10.1002/cmdc.202300106
Abstract: The mitochondrial calcium uniporter (MCU) is a transmembrane protein that is responsible for mediating mitochondrial calcium (mCa2+) uptake. Given this critical function, the MCU has been implicated as an important target for addressing various human… read more here.
Keywords: calcium uniporter; metal based; metal; mitochondrial calcium ... See more keywords
Unbalanced ER‐mitochondrial calcium homeostasis promotes mitochondrial dysfunction and associated apoptotic pathways activation in methylmercury exposed rat cortical neurons
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23136
Abstract: Methylmercury (MeHg) is a cumulative environmental pollutant that can easily cross the blood–brain barrier and cause damage to the brain, mainly targeting the central nervous system. The purpose of this study is to investigate the… read more here.
Keywords: calcium; ca2; methylmercury; cortical neurons ... See more keywords
Patch-Clamp Analysis of the Mitochondrial Calcium Uniporter.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9018-4_7
Abstract: Mitochondria accumulate significant amounts of calcium when cytosolic calcium is elevated above the resting levels of 50-100 nM during signaling events. This calcium uptake is primarily mediated by a macromolecular protein assembly called mitochondrial calcium uniporter… read more here.
Keywords: calcium; calcium uniporter; patch clamp; mitochondrial calcium ... See more keywords
Metabolite regulation of the mitochondrial calcium uniporter channel.
Sign Up to like & getrecommendations! Published in 2020 at "Cell calcium"
DOI: 10.1016/j.ceca.2020.102288
Abstract: Calcium (Ca2+) is known to stimulate mitochondrial bioenergetics through the modulation of TCA cycle dehydrogenases and electron transport chain (ETC) complexes. This is hypothesized to be an essential pathway of energetic control to meet cellular… read more here.
Keywords: mitochondrial bioenergetics; uniporter channel; calcium uniporter; mitochondrial calcium ... See more keywords
Parvalbumin affects skeletal muscle trophism through modulation of mitochondrial calcium uptake
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DOI: 10.1016/j.celrep.2021.109087
Abstract: Summary Parvalbumin (PV) is a cytosolic Ca2+-binding protein highly expressed in fast skeletal muscle, contributing to an increased relaxation rate. Moreover, PV is an “atrogene” downregulated in most muscle atrophy conditions. Here, we exploit mice… read more here.
Keywords: skeletal muscle; muscle; mitochondrial calcium; hypertrophy ... See more keywords
Mitochondrial calcium uniporter involved in foodborne mycotoxin-induced hepatotoxicity.
Sign Up to like & getrecommendations! Published in 2022 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2022.113535
Abstract: Foodborne mycotoxins are toxic metabolites that are produced by fungi. The widespread contamination of food and its by-products by mycotoxins is a global food safety problem that potentially threatens public health and other exposed animals.… read more here.
Keywords: uniporter involved; mitochondrial calcium; hepatotoxicity; induced hepatotoxicity ... See more keywords
Neuronal mitochondrial calcium uniporter deficiency exacerbates axonal injury and suppresses remyelination in mice subjected to experimental autoimmune encephalomyelitis
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DOI: 10.1016/j.expneurol.2020.113430
Abstract: High-capacity mitochondrial calcium (Ca2+) uptake by the mitochondrial Ca2+ uniporter (MCU) is strategically positioned to support the survival and remyelination of axons in multiple sclerosis (MS) by undocking mitochondria, buffering Ca2+ and elevating adenosine triphosphate… read more here.
Keywords: remyelination; mcu; eae thy1; mitochondrial calcium ... See more keywords
Mitochondrial calcium imbalance in Parkinson’s disease
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DOI: 10.1016/j.neulet.2017.08.044
Abstract: Multiple factors are involved in the mechanism(s) of neuronal loss in neurodegenerative disorders whilst mitochondria are thought to play a central role in neurodegeneration of Parkinson's disease. Mitochondria are vital to cellular functions by supplying… read more here.
Keywords: calcium; mitochondrial calcium; ca2; parkinson disease ... See more keywords