The nature compound dehydrocrenatidine exerts potent antihepatocellular carcinoma by destroying mitochondrial complexes in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7398
Abstract: Cumulative evidence indicates that mitochondria dysfunction plays an important role in tumour treatment. Given the limited efficacy and toxicity of current mitochondria‐targeted drugs, research into effective mitochondria‐targeted anticancer agents remains an irresistible general trend. In… read more here.
Keywords: vitro vivo; compound; mitochondrial complexes; dec ... See more keywords
Molecular Signatures of Mitochondrial Complexes Involved in Alzheimer's Disease via Oxidative Phosphorylation and Retrograde Endocannabinoid Signaling Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/9565545
Abstract: Objective The inability to intervene in Alzheimer's disease (AD) forces the search for promising gene-targeted therapies. This study was aimed at exploring molecular signatures and mechanistic pathways to improve the diagnosis and treatment of AD.… read more here.
Keywords: mitochondrial complexes; hub; oxidative phosphorylation; molecular signatures ... See more keywords
Silibinin inhibits PM2.5-induced liver triglyceride accumulation through enhancing the function of mitochondrial Complexes I and II
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2024.1435230
Abstract: Background The standardized extract of milk thistle seeds, known as silibinin, has been utilized in herbal medicine for over two centuries, with the aim of safeguarding the liver against the deleterious effects of various toxic… read more here.
Keywords: mitochondrial complexes; function; accumulation; silibinin ... See more keywords
Dual Regulation of Mitochondrial Complexes by H2S via S-Sulfhydration Controls Respiration in Type 1 Diabetic Hearts
Sign Up to like & getrecommendations! Published in 2025 at "Biomolecules"
DOI: 10.3390/biom15081197
Abstract: Hydrogen sulfide (H2S) has been established to regulate mitochondrial respiration and ATP production, but whether the regulation is through S-sulfhydration (-SSH) of mitochondrial complexes is not well understood. Recently, H2S is known to exert diverse… read more here.
Keywords: diabetic hearts; respiration; type diabetic; mitochondrial complexes ... See more keywords