Apigenin ameliorates oxidative stress and mitochondrial damage induced by multiwall carbon nanotubes in rat kidney mitochondria
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22762
Abstract: The toxicity of carbon nanotubes (CNTs) toward the mitochondria of the kidney is not fully recognized and still needs further research. Apigenin (APG) is known as a flavonoid compound and natural antioxidant. The purpose of… read more here.
Keywords: mitochondrial damage; oxidative stress; carbon nanotubes; kidney mitochondria ... See more keywords
Polystyrene exacerbates cadmium-induced mitochondrial damage to lung by blocking autophagy in mice.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23804
Abstract: Cadmium (Cd) is an environmental heavy metal, and its accumulation is harmful to animal and human health. The cytotoxicity of Cd includes oxidative stress, apoptosis, and mitochondrial histopathological changes. Furthermore, polystyrene (PS) is a kind… read more here.
Keywords: damage; induced mitochondrial; blocking autophagy; lung ... See more keywords
Lidocaine Attenuates Cognitive Impairment After Isoflurane Anesthesia by Reducing Mitochondrial Damage
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemical Research"
DOI: 10.1007/s11064-019-02799-0
Abstract: Mitochondrial dysfunction has been proposed to be one of the earliest triggering events in isoflurane-induced neuronal damage. Lidocaine has been demonstrated to attenuate the impairment of cognition in aged rats induced by isoflurane in our… read more here.
Keywords: mitochondrial damage; cognitive impairment; lidocaine; damage ... See more keywords
MDM2 contributes to oxidized low-density lipoprotein-induced inflammation through modulation of mitochondrial damage in endothelial cells.
Sign Up to like & getrecommendations! Published in 2020 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2020.05.020
Abstract: BACKGROUND AND AIMS Murine double minute-2 (MDM2) has been poorly studied in cardiovascular diseases. The aim of the present study was to determine the biological role of MDM2 in inflammation activation and mitochondrial damage in… read more here.
Keywords: mitochondrial damage; mdm2; inflammation; mdm2 overexpression ... See more keywords
Ultrastructural characterization of mitochondrial damage in experimental autoimmune neuritis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2020.577218
Abstract: Data are sparse about mitochondrial damage in GBS and in its most frequently employed animal model, experimental autoimmune neuritis (EAN). We here characterized changes in mitochondrial content and morphology at different time points during EAN… read more here.
Keywords: mitochondrial damage; autoimmune neuritis; schwann cells; ultrastructural characterization ... See more keywords
A high-throughput real-time in vitro assay using mitochondrial targeted roGFP for screening of drugs targeting mitochondria
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2018.10.013
Abstract: Most toxic compounds including cancer drugs target mitochondria culminating in its permeabilization. Cancer drug-screening and toxicological testing of compounds require cost-effective and sensitive high-throughput methods to detect mitochondrial damage. Real-time methods for detection of mitochondrial… read more here.
Keywords: mitochondrial damage; real time; biology; rogfp ... See more keywords
Targeting IFN-γ-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101159
Abstract: Highlights • GILT is upregulated in chemoresistant LSC-enriched CD34+ progenitor cells.• Inhibition of GILT in AML cells sensitized them to Ara-C treatment through ROS-mediated mitochondrial damage and apoptosis.• PI3K/Akt/NRF2 pathway inhibition is critical for the… read more here.
Keywords: mitochondrial damage; mediated mitochondrial; ros mediated; targeting ifn ... See more keywords
A Cu(I)-based Fenton-like agent inducing mitochondrial damage for photo-assisted enhanced chemodynamic therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Dalton transactions"
DOI: 10.1039/d3dt00317e
Abstract: Increasing the reactive oxygen species (ROS) content at the tumor site is one of the effective strategies to promote intracellular oxidative stress and improve therapeutic efficiency. Herein, an atomically precise cinnamaldehyde-derived metal-organic Cu(I) complex (denoted… read more here.
Keywords: fenton like; mitochondrial damage; based fenton; like agent ... See more keywords
The retroviral restriction factor TRIM5/TRIM5α regulates mitochondrial quality control
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2084863
Abstract: ABSTRACT The protein TRIM5 is under intensive investigation related to its roles in antiviral defense, yet its underlying mechanisms of action remain elusive. In our study, we performed an unbiased identification of TRIM5-interacting partners and… read more here.
Keywords: mitochondrial quality; mitochondrial damage; quality control; trim5 ... See more keywords
Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism
Sign Up to like & getrecommendations! Published in 2020 at "Brain"
DOI: 10.1093/brain/awaa246
Abstract: Parkin/PINK1 deficiency impairs mitophagy in mice, leading to the release of mitochondrial DNA (mtDNA) and triggering inflammation. Borsche et al. now demonstrate elevated serum Interleukin 6 and circulating cell-free mtDNA also in patients with Parkin/PINK1… read more here.
Keywords: mitochondrial damage; inflammation highlights; highlights biomarkers; inflammation ... See more keywords
Peripheral Blood Mononuclear Cells Demonstrate Mitochondrial Damage Clearance During Sepsis
Sign Up to like & getrecommendations! Published in 2019 at "Critical Care Medicine"
DOI: 10.1097/ccm.0000000000003681
Abstract: Objectives: Metabolic derangements in sepsis stem from mitochondrial injury and contribute significantly to organ failure and mortality; however, little is known about mitochondrial recovery in human sepsis. We sought to test markers of mitochondrial injury… read more here.
Keywords: blood mononuclear; sepsis; blood; mitochondrial damage ... See more keywords