Mitochondrial-derived compartments: A "fusel alcohol generator" in yeast?
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.08.032
Abstract: Schuler et al. (2021) demonstrate that mitochondrial-derived compartments protect cells from amino acid toxicity by activation of amino acid catabolism through the Ehrlich pathway, thus highlighting the incredible plasticity of mitochondria in rewiring cellular metabolism. read more here.
Keywords: generator yeast; fusel alcohol; mitochondrial derived; alcohol generator ... See more keywords
The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-08372-5
Abstract: Mitochondrial-derived peptides (MDPs) and their analogs have emerged as wide-spectrum, stress response factors protective in amyloid disease models. MDP cytoprotective functions are generally attributed to anti-apoptotic activity, however, little is known about their capacity to… read more here.
Keywords: humanin like; mitochondrial derived; small humanin; derived peptides ... See more keywords
Mitochondrial-Derived Peptides Exacerbate Senescence.
Sign Up to like & getrecommendations! Published in 2018 at "Rejuvenation research"
DOI: 10.1089/rej.2018.2114
Abstract: Mitochondrial-derived peptides (MDPs), encoded by mitochondrial DNA, play a cytoprotective role by helping preserve mitochondrial function and cell viability under stressful conditions. Humanin and its homologs and MOTS-c are two of several MDPs hypothesized to… read more here.
Keywords: senescent cells; mitochondrial derived; exacerbate senescence; derived peptides ... See more keywords
Mitochondrial derived peptide MOTS‐c prevents the development of heart failure under pressure overload conditions in mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17551
Abstract: MOTS‐c, a mitochondrial‐derived peptide (MDP), has been shown to have multiple biological activities such as antioxidation, anti‐inflammation, and anti‐apoptosis properties. In the present study, we aimed at evaluating the therapeutic effect of MOTS‐c peptide in… read more here.
Keywords: heart failure; derived peptide; mitochondrial derived; heart ... See more keywords
Mitochondrial-derived peptides as a novel intervention for obesity and cardiac diseases: bench evidence for potential bedside application
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Pathology"
DOI: 10.1136/jcp-2022-208321
Abstract: Currently, obesity is the most common major health problem for people worldwide. Obesity is known to be a significant risk factor for several diseases, including metabolic syndrome, insulin resistance and type 2 diabetes, eventually leading… read more here.
Keywords: application; pathology; evidence; mitochondrial derived ... See more keywords
Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells
Sign Up to like & getrecommendations! Published in 2017 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2017/1675230
Abstract: Age-related macular degeneration (AMD) is the leading cause of severe and irreversible vision loss and is characterized by progressive degeneration of the retina resulting in loss of central vision. The retinal pigment epithelium (RPE) is… read more here.
Keywords: endoplasmic reticulum; mitochondrial derived; reticulum stress; stress ... See more keywords
Abstract 16422: Lower Mitochondrial-derived Peptide Humanin in Young Adults Born Preterm vs. Term and Association With Left Ventricular Ejection Fraction
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.16422
Abstract: Introduction: Preterm (PT) birth is associated with increased risk of cardiovascular diseases (CVD) and heart failure. We previously reported left ventricular (LV) mitochondrial dysfunction in a ra... read more here.
Keywords: derived peptide; abstract 16422; 16422 lower; lower mitochondrial ... See more keywords
Mitochondrial‐derived vesicles retain membrane potential and contain a functional ATP synthase
Sign Up to like & getrecommendations! Published in 2023 at "EMBO Reports"
DOI: 10.15252/embr.202256114
Abstract: Vesicular transport is a means of communication. While cells can communicate with each other via secretion of extracellular vesicles, less is known regarding organelle‐to organelle communication, particularly in the case of mitochondria. Mitochondria are responsible… read more here.
Keywords: synthase; atp synthase; derived vesicles; mitochondrial derived ... See more keywords
Mitochondrial-Derived Vesicles as Candidate Biomarkers in Parkinson’s Disease: Rationale, Design and Methods of the EXosomes in PArkiNson Disease (EXPAND) Study
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20102373
Abstract: The progressive loss of dopaminergic neurons in the nigro-striatal system is a major trait of Parkinson’s disease (PD), manifesting clinically as motor and non-motor symptoms. Mitochondrial dysfunction and oxidative stress are alleged pathogenic mechanisms underlying… read more here.
Keywords: disease expand; derived vesicles; mitochondrial derived; disease ... See more keywords
Mitochondrial-Derived Vesicles—Link to Extracellular Vesicles and Implications in Cardiovascular Disease
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032637
Abstract: Mitochondria are dynamic organelles regulating metabolism, cell death, and energy production. Therefore, maintaining mitochondrial health is critical for cellular homeostasis. Mitophagy and mitochondrial reorganization via fission and fusion are established mechanisms for ensuring mitochondrial quality.… read more here.
Keywords: extracellular vesicles; cardiovascular disease; derived vesicles; mitochondrial derived ... See more keywords