Induced effect of zinc oxide nanoparticles on human acute myeloid leukemia cell apoptosis by regulating mitochondrial division
Sign Up to like & getrecommendations! Published in 2022 at "IUBMB Life"
DOI: 10.1002/iub.2615
Abstract: Zinc oxide nanoparticles (ZnO NPs) have exhibited excellent anti‐tumor properties; the present study aimed to elucidate the underlying mechanism of ZnO NPs induced apoptosis in acute myeloid leukemia (AML) cells by regulating mitochondrial division. THP‐1… read more here.
Keywords: mitochondrial division; acute myeloid; zno nps; apoptosis ... See more keywords
Discovery and characterization of selective small molecule inhibitors of the mammalian mitochondrial division dynamin, DRP1.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.03.189
Abstract: Balanced rates of mitochondrial division and fusion are required to maintain mitochondrial function, as well as cellular and organismal homeostasis. In mammals, the cellular machines that mediate these processes are dynamin-related GTPases; the cytosolic DRP1… read more here.
Keywords: division dynamin; mitochondrial division; division; dynamin drp1 ... See more keywords
The Complex Dance of Organelles during Mitochondrial Division.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2020.12.005
Abstract: Mitochondria are dynamic organelles that undergo cycles of fission and fusion events depending on cellular requirements. During mitochondrial division, the GTPase dynamin-related protein-1 is recruited to endoplasmic reticulum (ER)-induced mitochondrial constriction sites where it drives… read more here.
Keywords: organelles mitochondrial; division; complex dance; mitochondrial division ... See more keywords
Cyanidioschyzon merolae aurora kinase phosphorylates evolutionarily conserved sites on its target to regulate mitochondrial division
Sign Up to like & getrecommendations! Published in 2019 at "Communications Biology"
DOI: 10.1038/s42003-019-0714-x
Abstract: The mitochondrion is an organelle that was derived from an endosymbiosis. Although regulation of mitochondrial growth by the host cell is necessary for the maintenance of mitochondria, it is unclear how this regulatory mechanism was… read more here.
Keywords: division; cyanidioschyzon merolae; merolae aurora; aurora kinase ... See more keywords
Myosin II proteins are required for organization of calcium-induced actin networks upstream of mitochondrial division.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-01-0005
Abstract: The formin INF2 polymerizes a calcium-activated cytoplasmic network of actin filaments, which we refer to as CIA (calcium-induced actin). CIA plays important roles in multiple cellular processes, including mitochondrial dynamics and vesicle transport. Here, we… read more here.
Keywords: mitochondrial division; myosin; induced actin; calcium ... See more keywords
Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity
Sign Up to like & getrecommendations! Published in 2019 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy335
Abstract: Abstract The purpose of our study was to better understand the effects of mitochondrial-division inhibitor 1 (Mdivi-1) on mitochondrial fission, mitochondrial biogenesis, electron transport activities and cellular protection. In recent years, researchers have found excessive… read more here.
Keywords: fission; n2a cells; mitochondrial fission; mitochondrial division ... See more keywords