A ROS‐Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro‐Angiogenesis for Efficient Treatment of Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200990
Abstract: Mitochondrial dysfunction of cardiomyocytes (CMs) has been identified as a significant pathogenesis of early myocardial infarction (MI). However, only a few agents or strategies have been developed to improve mitochondrial dysfunction for the effective MI… read more here.
Keywords: hydrogel; liposomal composite; mitochondrial dysfunction; treatment ... See more keywords
Injectable Nanocomposite Hydrogels for Intervertebral Disc Degeneration: Combating Oxidative Stress, Mitochondrial Dysfunction, and Ferroptosis
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DOI: 10.1002/adhm.202403892
Abstract: Intervertebral disc degeneration (IVDD) is a major cause of low back pain, where oxidative stress and mitochondrial dysfunction are key contributors. Additionally, ferroptosis, an iron‐dependent form of cell death, is identified as a critical mechanism… read more here.
Keywords: disc degeneration; intervertebral disc; oxidative stress; mitochondrial dysfunction ... See more keywords
Ameliorating Mitochondrial Dysfunction of Neurons by Biomimetic Targeting Nanoparticles Mediated Mitochondrial Biogenesis to Boost the Therapy of Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300758
Abstract: Mitochondrial dysfunction of neurons is the core pathogenesis of incurable Parkinson's disease (PD). It is crucial to ameliorate the mitochondrial dysfunction of neurons for boosting the therapy of PD. Herein, the remarkable promotion of mitochondrial… read more here.
Keywords: mitochondrial biogenesis; parkinson disease; dysfunction neurons; mitochondrial dysfunction ... See more keywords
Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti-Resorptive Therapy.
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DOI: 10.1002/advs.202517586
Abstract: Mitochondria-driven macrophage dysregulation contributes significantly to inflammatory disease progression; however, the mechanism underlying bisphosphonate-related osteonecrosis of the jaw (BRONJ) remains unclear. This study demonstrates that zoledronic acid (ZA) disrupts mitochondrial bioenergetic function in macrophages, leading… read more here.
Keywords: therapy; mitochondrial dysfunction; osteonecrosis; rescuing mitochondrial ... See more keywords
Evaluation of flubendiamide-induced mitochondrial dysfunction and metabolic changes in Helicoverpa armigera (Hubner).
Sign Up to like & getrecommendations! Published in 2017 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.21401
Abstract: Phthalic acid diamide insecticides are the most effective insecticides used against most of the lepidopteran pests including Helicoverpa armigera, a polyphagous pest posing threat to several crops worldwide. The present studies were undertaken to understand… read more here.
Keywords: helicoverpa armigera; dose dependent; mitochondrial dysfunction; flubendiamide induced ... See more keywords
Epigenetics and mitochondrial dysfunction insights into the impact of the progression of non‐alcoholic fatty liver disease
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3763
Abstract: A metabolic problem occurs when regular functions of the body are disrupted due to an undesirable imbalance. Nonalcoholic fatty liver disease (NAFLD) is considered as one of the most common in this category. NAFLD is… read more here.
Keywords: fatty liver; disease; mitochondrial dysfunction; dysfunction insights ... See more keywords
Neuroprotective effect of Na+ /H+ exchangers isoform-1 inactivation against 6-hydroxydopamine-induced mitochondrial dysfunction and neuronal apoptosis in Parkinson's disease models.
Sign Up to like & getrecommendations! Published in 2021 at "Drug development research"
DOI: 10.1002/ddr.21799
Abstract: Parkinson's disease (PD) is a disabling neurodegenerative disease mainly caused by degeneration of mesencephalic dopaminergic neurons in the substantia nigra pars compacta (SNpc). The neuroprotective role of Na+ /H+ exchangers isoform-1 (NHE1) inactivation in cerebral… read more here.
Keywords: mitochondrial dysfunction; apoptosis; disease; inactivation ... See more keywords
Mycotoxin‐assisted mitochondrial dysfunction and cytotoxicity: Unexploited tools against proliferative disorders
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DOI: 10.1002/iub.1932
Abstract: Mitochondria are the powerhouse of cells, which upon dysfunctions may lead to several diseases. Mycotoxins are the toxic secondary metabolites from fungi which are capable of causing diseases and death in humans and animals. They… read more here.
Keywords: dysfunction; cytotoxicity unexploited; assisted mitochondrial; mitochondrial dysfunction ... See more keywords
PLEKHF1 Induces Mitochondrial Dysfunction to Inhibit Osteosarcoma Growth and Metastasis
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DOI: 10.1002/iub.70048
Abstract: Osteosarcoma (OS) is an uncommon malignancy with stagnant survival rates over the past four decades and early‐stage metastasis, predominantly affecting children and adolescents. This study identified significant metabolic differences between metastatic and non‐metastatic OS samples… read more here.
Keywords: mitochondrial dysfunction; plekhf1; growth metastasis;
Sulforaphane prevents quinolinic acid‐induced mitochondrial dysfunction in rat striatum
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DOI: 10.1002/jbt.21837
Abstract: Quinolinic acid (QA) triggers striatal neuronal death by an excitotoxic cascade that involves oxidative stress, which in turns is tightly linked to mitochondria. Mitochondrial dysfunction is a molecular feature described in several brain pathologies. In… read more here.
Keywords: sulforaphane prevents; dysfunction; quinolinic acid; mitochondrial dysfunction ... See more keywords
Protective effect of hydroxytyrosol in arsenic‐induced mitochondrial dysfunction in rat brain
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DOI: 10.1002/jbt.21906
Abstract: The present study was planned to investigate the protective effect of hydroxytyrosol (HT) against arsenic (As)‐induced mitochondrial dysfunction in rat brain. Rats exposed to sodium arsenite (25 ppm for 8 weeks) showed decreased mitochondrial complexes… read more here.
Keywords: protective effect; dysfunction; effect hydroxytyrosol; mitochondrial dysfunction ... See more keywords