A ROS‐Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro‐Angiogenesis for Efficient Treatment of Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200990
Abstract: Mitochondrial dysfunction of cardiomyocytes (CMs) has been identified as a significant pathogenesis of early myocardial infarction (MI). However, only a few agents or strategies have been developed to improve mitochondrial dysfunction for the effective MI… read more here.
Keywords: hydrogel; liposomal composite; mitochondrial dysfunction; treatment ... See more keywords
Ameliorating Mitochondrial Dysfunction of Neurons by Biomimetic Targeting Nanoparticles Mediated Mitochondrial Biogenesis to Boost the Therapy of Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300758
Abstract: Mitochondrial dysfunction of neurons is the core pathogenesis of incurable Parkinson's disease (PD). It is crucial to ameliorate the mitochondrial dysfunction of neurons for boosting the therapy of PD. Herein, the remarkable promotion of mitochondrial… read more here.
Keywords: mitochondrial biogenesis; parkinson disease; dysfunction neurons; mitochondrial dysfunction ... See more keywords
Evaluation of flubendiamide-induced mitochondrial dysfunction and metabolic changes in Helicoverpa armigera (Hubner).
Sign Up to like & getrecommendations! Published in 2017 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.21401
Abstract: Phthalic acid diamide insecticides are the most effective insecticides used against most of the lepidopteran pests including Helicoverpa armigera, a polyphagous pest posing threat to several crops worldwide. The present studies were undertaken to understand… read more here.
Keywords: helicoverpa armigera; dose dependent; mitochondrial dysfunction; flubendiamide induced ... See more keywords
Epigenetics and mitochondrial dysfunction insights into the impact of the progression of non‐alcoholic fatty liver disease
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3763
Abstract: A metabolic problem occurs when regular functions of the body are disrupted due to an undesirable imbalance. Nonalcoholic fatty liver disease (NAFLD) is considered as one of the most common in this category. NAFLD is… read more here.
Keywords: fatty liver; disease; mitochondrial dysfunction; dysfunction insights ... See more keywords
Neuroprotective effect of Na+ /H+ exchangers isoform-1 inactivation against 6-hydroxydopamine-induced mitochondrial dysfunction and neuronal apoptosis in Parkinson's disease models.
Sign Up to like & getrecommendations! Published in 2021 at "Drug development research"
DOI: 10.1002/ddr.21799
Abstract: Parkinson's disease (PD) is a disabling neurodegenerative disease mainly caused by degeneration of mesencephalic dopaminergic neurons in the substantia nigra pars compacta (SNpc). The neuroprotective role of Na+ /H+ exchangers isoform-1 (NHE1) inactivation in cerebral… read more here.
Keywords: mitochondrial dysfunction; apoptosis; disease; inactivation ... See more keywords
Mycotoxin‐assisted mitochondrial dysfunction and cytotoxicity: Unexploited tools against proliferative disorders
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1932
Abstract: Mitochondria are the powerhouse of cells, which upon dysfunctions may lead to several diseases. Mycotoxins are the toxic secondary metabolites from fungi which are capable of causing diseases and death in humans and animals. They… read more here.
Keywords: dysfunction; cytotoxicity unexploited; assisted mitochondrial; mitochondrial dysfunction ... See more keywords
Sulforaphane prevents quinolinic acid‐induced mitochondrial dysfunction in rat striatum
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.21837
Abstract: Quinolinic acid (QA) triggers striatal neuronal death by an excitotoxic cascade that involves oxidative stress, which in turns is tightly linked to mitochondria. Mitochondrial dysfunction is a molecular feature described in several brain pathologies. In… read more here.
Keywords: sulforaphane prevents; dysfunction; quinolinic acid; mitochondrial dysfunction ... See more keywords
Protective effect of hydroxytyrosol in arsenic‐induced mitochondrial dysfunction in rat brain
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.21906
Abstract: The present study was planned to investigate the protective effect of hydroxytyrosol (HT) against arsenic (As)‐induced mitochondrial dysfunction in rat brain. Rats exposed to sodium arsenite (25 ppm for 8 weeks) showed decreased mitochondrial complexes… read more here.
Keywords: protective effect; dysfunction; effect hydroxytyrosol; mitochondrial dysfunction ... See more keywords
Eriodictyol regulated ferroptosis, mitochondrial dysfunction, and cell viability via Nrf2/HO-1/NQO1 signaling pathway in ovarian cancer cells.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23368
Abstract: This study aimed to investigate the antitumor effect and the underlying molecular mechanism of eriodictyol on ovarian cancer cells. CaoV3 and A2780 were exposed to eriodictyol at different concentrations of 0-800 μM. Cell apoptosis and viability… read more here.
Keywords: cell; ovarian cancer; mitochondrial dysfunction; viability ... See more keywords
Autophagic flux inhibition, apoptosis, and mitochondrial dysfunction in bile acids‐induced impairment of human placental trophoblast
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30774
Abstract: Intrahepatic cholestasis of pregnancy (ICP) is a common pregnancy‐specific disease, characterized by increased bile acid levels and adverse fetal outcomes. We previously reported excessive bile acids led to dysfunction of placental trophoblasts in ICP. However,… read more here.
Keywords: autophagic flux; mitochondrial dysfunction; bile acids; dysfunction ... See more keywords
Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.104
Abstract: Background: Although primarily a neurodegenerative process, there is increasing awareness of peripheral disease mechanisms in Parkinson's disease. To investigate disease processes in accessible patient cells, we studied peripheral blood mononuclear cells in recently diagnosed PD… read more here.
Keywords: cells mitochondrial; dysfunction increased; increased glycolysis; blood ... See more keywords