The mitochondrial fission factor FIS1 promotes stemness of human lung cancer stem cells via mitophagy
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13207
Abstract: Mitophagy, a form of autophagy, plays a role in cancer development, progression and recurrence. Cancer stem cells (CSCs) also play a key role in these processes, although it not known whether mitophagy can regulate the… read more here.
Keywords: cancer stem; mitochondrial fission; cancer; fis1 ... See more keywords
The role of Cdk5‐mediated Drp1 phosphorylation in Aβ1‐42 induced mitochondrial fission and neuronal apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26680
Abstract: Alzheimer's disease, one of the most common neurodegenerative diseases, is pathologically characterized by Amyloid beta containing plaques and neurofibrillary tangles. Amyloid beta (Aβ) induces neuronal apoptosis through the intracellular Ca2+ increase, subsequent hyperactivation of cyclin‐dependent… read more here.
Keywords: fission; neuronal apoptosis; mitochondrial fission; cdk5 ... See more keywords
BI1 alleviates cardiac microvascular ischemia‐reperfusion injury via modifying mitochondrial fission and inhibiting XO/ROS/F‐actin pathways
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27308
Abstract: Pathogenesis of cardiac microvascular ischemia‐reperfusion (IR) injury is associated with excessive mitochondrial fission. However, the upstream mediator of mitochondrial fission remains obscure. Bax inhibitor 1 (BI1) is linked to multiple mitochondrial functions, and there have… read more here.
Keywords: reperfusion injury; fission; cardiac microvascular; mitochondrial fission ... See more keywords
Suppression of Tafazzin promotes thyroid cancer apoptosis via activating the JNK signaling pathway and enhancing INF2‐mediated mitochondrial fission
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28287
Abstract: Tafazzin has been found to be associated with tumor progression. Mitochondrial homeostasis regulates cancer cell viability and metastasis. However, the roles of Tafazzin and mitochondrial homeostasis in thyroid cancer have not been explored. The aim… read more here.
Keywords: jnk; apoptosis; thyroid cancer; mitochondrial fission ... See more keywords
Rapamycin encourages the maintenance of mitochondrial dynamic balance and mitophagy activity for improving developmental competence of blastocysts in porcine embryos in vitro
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23681
Abstract: Rapamycin induces autophagosome formation and activity during oocyte maturation, improved fertilization ability of matured oocytes, and early embryonic developmental competence. However, potential changes in mitochondrial fission and mitophagy via regulation of autophagy in early porcine… read more here.
Keywords: porcine embryos; mitochondrial fission; rapamycin; activity ... See more keywords
Proteomics Analysis of Candida albicans dnm1 Haploid Mutant Unraveled the Association between Mitochondrial Fission and Antifungal Susceptibility
Sign Up to like & getrecommendations! Published in 2019 at "PROTEOMICS"
DOI: 10.1002/pmic.201900240
Abstract: Candida albicans is a major fungal pathogen, accounting for approximately 15% of healthcare infections with associated mortality as high as 40% in the case of systemic candidiasis. Antifungal agents for C. albicans infections are limited,… read more here.
Keywords: susceptibility; association; candida albicans; mitochondrial fission ... See more keywords
Imaging Dynamin-Related Protein 1 (Drp1)-Mediated Mitochondrial Fission in Living Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0676-6_16
Abstract: Mitochondria form highly dynamic networks that continuously undergo fission and fusion. Dynamin-related protein 1 (Drp1), a key regulator of mitochondrial division, self-assembles into a helical polymer around pre-marked scission sites and generates the constriction force… read more here.
Keywords: fission; mitochondrial fission; related protein; dynamin related ... See more keywords
Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: mechanisms of action in vitro and associations with cognition in rats and children
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Toxicology"
DOI: 10.1007/s00204-019-02390-0
Abstract: Fluoride neurotoxicity is associated with mitochondrial disruption. Mitochondrial fission/fusion dynamics is crucial to maintain functional mitochondria, yet little is known about how fluoride perturbs this dynamics and whether such perturbation contributes to impaired neurodevelopment. Here… read more here.
Keywords: apoptosis; fluoride neurotoxicity; fission; inhibition ... See more keywords
CDK4 and CDK5 Inhibition Have Comparable Mild Hypothermia Effects in Preventing Drp1-Dependent Mitochondrial Fission and Neuron Death Induced by MPP+
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-02014-0
Abstract: Mild hypothermia has promising effects in the treatment of acute brain insults and also affects cell cycle progression. Mitochondrial dynamics, fusion and fission, are changed along with the cell cycle and disrupted in neurodegenerative diseases,… read more here.
Keywords: hypothermia; mild hypothermia; fission; cdk4 ... See more keywords
Sirtuin 3 inhibition induces mitochondrial stress in tongue cancer by targeting mitochondrial fission and the JNK-Fis1 biological axis
Sign Up to like & getrecommendations! Published in 2019 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-019-00970-8
Abstract: Sirtuin 3 (Sirt3)-modified mitochondrial fission participates in the progression of several types of cancers. However, its role in tongue cancer requires investigation. The aim of our study is to determine whether Sirt3 knockdown regulates the… read more here.
Keywords: tongue cancer; mitochondrial fission; jnk;
BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy
Sign Up to like & getrecommendations! Published in 2020 at "Protein & Cell"
DOI: 10.1007/s13238-020-00713-x
Abstract: Dysregulation of circadian rhythms associates with cardiovascular disorders. It is known that deletion of the core circadian gene Bmal1 in mice causes dilated cardiomyopathy. However, the biological rhythm regulation system in mouse is very different… read more here.
Keywords: protein; bmal1; function; mitochondrial fission ... See more keywords