Mitochondrial Dynamics: Coupling Mitochondrial Fitness with Healthy Aging.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2017.01.003
Abstract: Aging is associated with a decline in mitochondrial function and the accumulation of abnormal mitochondria. However, the precise mechanisms by which aging promotes these mitochondrial alterations and the role of the latter in aging are… read more here.
Keywords: healthy aging; dynamics coupling; fitness healthy; mitochondrial dynamics ... See more keywords
The central role of mitochondrial fitness on antiviral defenses: An advocacy for physical activity during the COVID-19 pandemic
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.101976
Abstract: Mitochondria are central regulators of cellular metabolism, most known for their role in energy production. They can be “enhanced” by physical activity (including exercise), which increases their integrity, efficiency and dynamic adaptation to stressors, in… read more here.
Keywords: cardiorespiratory fitness; fitness; role; mitochondrial fitness ... See more keywords
Transcription factor EB coordinates environmental cues to regulate T regulatory cells’ mitochondrial fitness and function
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2205469119
Abstract: Significance Here, we show that transcription factor EB (TFEB), thought to be a key regulator of autophagy and lysosome function, can be regulated by T regulatory (Treg)-related cues in a mechanistic target of rapamycin complex… read more here.
Keywords: function; environmental cues; mitochondrial fitness; transcription factor ... See more keywords
Complement C1q binding protein regulates T cells’ mitochondrial fitness to affect their survival, proliferation, and anti–tumor immune function
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15261
Abstract: T cells survival, proliferation, and anti–tumor response are closely linked to their mitochondrial health. Complement C1q binding protein (C1QBP) promotes mitochondrial fitness through regulation of mitochondrial metabolism and morphology. However, whether C1QBP regulates T cell… read more here.
Keywords: c1qbp; anti tumor; proliferation; tumor ... See more keywords
Low cardiorespiratory and mitochondrial fitness as risk factors in viral infections: implications for COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Sports Medicine"
DOI: 10.1136/bjsports-2020-103572
Abstract: Physical activity (PA) modulates immune system functions. Susceptibility to viral infection thereby depends on the volume and intensity of PA: regular moderate PA (up to 60% of maximal oxygen uptake for no more than 1… read more here.
Keywords: risk factors; fitness; cardiorespiratory mitochondrial; mitochondrial fitness ... See more keywords
Abstract P049: Circadian Clock Dysfunction Impairs Mitochondrial Fitness And Contributes To Myocardial Ischemic Injury
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DOI: 10.1161/hyp.76.suppl_1.p049
Abstract: Cardiac function is highly reliant on mitochondrial oxidative metabolism and fitness. The circadian clock is critically linked to vital physiological process including mitochondrial fission, fusion and quality control mechanisms. However, little is known of how… read more here.
Keywords: activity; circadian clock; mitochondrial fitness; injury ... See more keywords
Inhibition of TLR4 Signaling Affects Mitochondrial Fitness and Overcomes Bortezomib Resistance in Myeloma Plasma Cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12081999
Abstract: Multiple myeloma (MM) is a B-cell malignancy requiring inflammatory microenvironment signals for cell survival and proliferation. Despite improvements in pharmacological tools, MM remains incurable mainly because of drug resistance. The present study aimed to investigate… read more here.
Keywords: mitochondrial fitness; myeloma; inhibition tlr4; resistance ... See more keywords