Early mitochondrial fragmentation is a potential in vitro biomarker of environmental stress.
Sign Up to like & getrecommendations! Published in 2019 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2019.02.044
Abstract: Mitochondria are essential dynamic organelles that ordinarily balance between fragmentation and fusion. Under stress conditions, a shift toward fragmentation or hyper-fusion is observed as a pro-survival reaction. Fragmentation of mitochondria occurs within minutes or hours… read more here.
Keywords: environmental stress; vitro biomarker; stress; fragmentation ... See more keywords
Metformin alleviates lead-induced mitochondrial fragmentation via AMPK/Nrf2 activation in SH-SY5Y cells
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101626
Abstract: As a widely acknowledged environmental pollutant, lead (Pb) exhibits neurological toxicity primarily due to the vulnerability of neural system. It is suggested that Pb could perturb mitochondrial function, triggering the following disturbance of cellular homeostasis.… read more here.
Keywords: metformin; activation; fragmentation; fragmentation via ... See more keywords
Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1213-4
Abstract: Mitochondria contain their own genomes that, unlike nuclear genomes, are inherited only in the maternal line. Owing to a high mutation rate and low levels of recombination of mitrochondrial DNA (mtDNA), special selection mechanisms exist… read more here.
Keywords: mtdna; selection; deleterious mtdna; germline ... See more keywords
MicroRNA-101-3p Suppresses mTOR and Causes Mitochondrial Fragmentation and Cell Degeneration in COPD
Sign Up to like & getrecommendations! Published in 2022 at "Canadian Respiratory Journal"
DOI: 10.1155/2022/5933324
Abstract: Background Cigarette smoke is assumed to cause the loss of airway wall structure in chronic obstructive pulmonary disease (COPD) by reducing airway smooth muscle cell (ASMC) function. It also modifies mTOR activity, microRNA (miR)-101-3p expression,… read more here.
Keywords: copd; mitochondrial fragmentation; expression; mtor ... See more keywords
Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations
Sign Up to like & getrecommendations! Published in 2017 at "Neurology"
DOI: 10.1212/wnl.0000000000003491
Abstract: Objective: To investigate mitophagy in 5 patients with severe dominantly inherited optic atrophy (DOA), caused by depletion of OPA1 (a protein that is essential for mitochondrial fusion), compared with healthy controls. Methods: Patients with severe… read more here.
Keywords: opa1 mutations; mitophagy mitochondrial; optic atrophy; dysregulated mitophagy ... See more keywords
Mst1-Hippo pathway triggers breast cancer apoptosis via inducing mitochondrial fragmentation in a manner dependent on JNK–Drp1 axis
Sign Up to like & getrecommendations! Published in 2019 at "OncoTargets and therapy"
DOI: 10.2147/ott.s193787
Abstract: Background and objective Mst1-Hippo pathway and mitochondrial fragmentation participate in the progression of several types of cancers. However, their roles in breast cancer requires investigation. The aim of our study is to determine whether Mst1… read more here.
Keywords: fragmentation; mitochondrial fragmentation; breast cancer; mst1 ... See more keywords
Concerted Action of AMPK and Sirtuin-1 Induces Mitochondrial Fragmentation Upon Inhibition of Ca2+ Transfer to Mitochondria
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.00378
Abstract: Mitochondria are highly dynamic organelles constantly undergoing fusion and fission. Ca2+ regulates many aspects of mitochondrial physiology by modulating the activity of several mitochondrial proteins. We previously showed that inhibition of constitutive IP3R-mediated Ca2+ transfer… read more here.
Keywords: ca2 transfer; inhibition; fragmentation; mitochondrial fragmentation ... See more keywords
Mitochondrial Fragmentation in a High Homocysteine Environment in Diabetic Retinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11020365
Abstract: Diabetic patients routinely have elevated homocysteine levels, and due to increase in oxidative stress, hyperhomocysteinemia is associated with increased mitochondrial damage. Mitochondrial homeostasis is directly related to the balance between their fission and fusion, and… read more here.
Keywords: fission; environment; homocysteine; mitochondrial fragmentation ... See more keywords
Microsporidia Promote Host Mitochondrial Fragmentation by Modulating DRP1 Phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147746
Abstract: Microsporidia are obligate intracellular parasites that infect a wide variety of hosts ranging from invertebrates to vertebrates. These parasites have evolved strategies to directly hijack host mitochondria for manipulating host metabolism and immunity. However, the… read more here.
Keywords: microsporidia; mitochondrial fragmentation; host mitochondrial; host ... See more keywords
NFATc3-dependent expression of miR-153-3p promotes mitochondrial fragmentation in cardiac hypertrophy by impairing mitofusin-1 expression
Sign Up to like & getrecommendations! Published in 2020 at "Theranostics"
DOI: 10.7150/thno.37181
Abstract: Mitochondrial dysfunction is involved in the pathogenesis of various cardiovascular disorders. Although mitochondrial dynamics, including changes in mitochondrial fission and fusion, have been implicated in the development of cardiac hypertrophy, the underlying molecular mechanisms remain… read more here.
Keywords: cardiac hypertrophy; mir 153; hypertrophy; expression ... See more keywords