hsa-miR-4485 regulates mitochondrial functions and inhibits the tumorigenicity of breast cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-017-1517-5
Abstract: The modulation of mitochondrial functions is important for maintaining cellular homeostasis. Mitochondria essentially depend on the import of RNAs and proteins encoded by the nuclear genome. MicroRNAs encoded in the nucleus can translocate to mitochondria… read more here.
Keywords: mir 4485; mitochondrial functions; breast; breast cancer ... See more keywords
Progesterone Modulates Mitochondrial Functions in Human Glioblastoma Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02382-1
Abstract: A substantial literature supports the notion that cancer is a metabolic disease. Mitochondria are sexually dimorphic, and progesterone (P4) plays a key regulatory role in mitochondrial functions. We investigated the effect of P4 on mitochondrial… read more here.
Keywords: gbm; effect; rate; human glioblastoma ... See more keywords
Mitochondrial Functions in Infection and Immunity
Sign Up to like & getrecommendations! Published in 2020 at "Trends in Cell Biology"
DOI: 10.1016/j.tcb.2020.01.006
Abstract: Mitochondria have a central role in regulating a range of cellular activities and host responses upon bacterial infection. Multiple pathogens affect mitochondria dynamics and functions to influence their intracellular survival or evade host immunity. On… read more here.
Keywords: immunity; infection immunity; functions infection; host ... See more keywords
Determination of mitochondrial functions and damage in kidney in female LeeSung minipigs with a high-fat diet-induced obesity.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of physiology and biochemistry"
DOI: 10.1080/13813455.2021.1949022
Abstract: The purpose of this study was to investigate the nexus between mitochondrial function and kidney injury by using a dietary-induced obese minipig model. Female Lee-Sung minipigs feeding a high-fat diet (HFD) for 6 months exhibited… read more here.
Keywords: fat diet; high fat; induced obesity; determination mitochondrial ... See more keywords
Bioengineered miR-34a modulates mitochondrial inner membrane protein 17 like 2 (MPV17L2) expression toward the control of cancer cell mitochondrial functions
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2076399
Abstract: ABSTRACT Genome-derived microRNAs (miRNAs or miRs) control post-transcriptional gene expression critical for various cellular processes. Recently, we have invented a novel platform technology to achieve high-yield production of fully humanized, bioengineered miRNA agents (hBERAs) for… read more here.
Keywords: mitochondrial functions; control; inner membrane; mitochondrial inner ... See more keywords
ZBTB11 dysfunction: spectrum of brain abnormalities, biochemical signature and cellular consequences
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac034
Abstract: Abstract Bi-allelic pathogenic variants in ZBTB11 have been associated with intellectual developmental disorder, autosomal recessive 69 (MRT69; OMIM 618383). We report five patients from three families with novel, bi-allelic variants in ZBTB11. We have expanded… read more here.
Keywords: mitochondrial functions; dysfunction spectrum; brain; zbtb11 dysfunction ... See more keywords
Alterations in mitochondrial functions and morphology in muscle and nonâmuscle tissues in type 1 diabetes: implications for metabolic health
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Physiology"
DOI: 10.1113/ep088096
Abstract: What is the topic of this review? Evidence of impaired mitochondrial functions and/or morphology in people with type 1 diabetes across various organ systems. What advances does it highlight? Impairments to mitochondrial functions and morphology… read more here.
Keywords: muscle; alterations mitochondrial; mitochondrial functions; type diabetes ... See more keywords
RUNX1 Upregulation Causes Mitochondrial Dysfunction via Regulating the PI3K-Akt Pathway in iPSC from Patients with Down Syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Molecules and Cells"
DOI: 10.14348/molcells.2023.2095
Abstract: Down syndrome (DS) is the most common autosomal aneuploidy caused by trisomy of chromosome 21. Previous studies demonstrated that DS affected mitochondrial functions, which may be associated with the abnormal development of the nervous system… read more here.
Keywords: runx1; mitochondrial functions; expression; mitochondrial dysfunction ... See more keywords
Rutin and Gallic Acid Regulates Mitochondrial Functions via the SIRT1 Pathway in C2C12 Myotubes
Sign Up to like & getrecommendations! Published in 2021 at "Antioxidants"
DOI: 10.3390/antiox10020286
Abstract: Mitochondria are highly dynamic organelles, balancing synthesis and degradation in response to increases in mitochondrial turnover (i.e., biogenesis, fusion, fission, and mitophagy) and function. The aim of this study was to investigate the role of… read more here.
Keywords: gallic acid; c2c12 myotubes; pathway c2c12; acid rutin ... See more keywords
Dietary Arginine Supplementation Improves Intestinal Mitochondrial Functions in Low-Birth-Weight Piglets but Not in Normal-Birth-Weight Piglets
Sign Up to like & getrecommendations! Published in 2021 at "Antioxidants"
DOI: 10.3390/antiox10121995
Abstract: Our previous studies revealed that L-arginine supplementation had beneficial effects on intestinal barrier functions of low-birth-weight (LBW) piglets, which were associated with the enhanced antioxidant capacity. Moreover, mitochondrial functions are closely related to the redox… read more here.
Keywords: arginine supplementation; birth weight; mitochondrial functions; weight piglets ... See more keywords
Interplay between Peripheral and Central Inflammation in Obesity-Promoted Disorders: The Impact on Synaptic Mitochondrial Functions
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21175964
Abstract: The metabolic dysfunctions induced by high fat diet (HFD) consumption are not limited to organs involved in energy metabolism but cause also a chronic low-grade systemic inflammation that affects the whole body including the central… read more here.
Keywords: plasticity; inflammation; systemic inflammation; obesity ... See more keywords