A Germline‐Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202203631
Abstract: Maintenance and differentiation of germline stem and progenitor cells (GSPCs) is important for sexual reproduction. Here, the authors identify zebrafish pld6 as a novel germline‐specific gene by cross‐analyzing different RNA sequencing results, and find that… read more here.
Keywords: maintenance differentiation; germline specific; mitochondrial fusion; germline ... See more keywords
Tamoxifen modulates mitochondrial dynamics through AMPK and MAPK during nutrition deprivation
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11853
Abstract: The interaction of cancer cells with their tumor microenvironment determines key events in the progression of the disease, therapeutic efficacy, and the development of drug resistance. Here, we presented evidence that tamoxifen support breast cancer… read more here.
Keywords: nutrition; nutrition deprivation; tamoxifen; mitochondrial fusion ... See more keywords
Sirt3 modulate renal ischemia‐reperfusion injury through enhancing mitochondrial fusion and activating the ERK‐OPA1 signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28918
Abstract: Mitochondrial fusion is linked to heart and liver ischemia‐reperfusion (IR) insult. Unfortunately, there is no report to elucidate the detailed influence of mitochondrial fusion in renal IR injury. This study principally investigated the mechanism by… read more here.
Keywords: opa1; mitochondrial fusion; renal injury; fusion ... See more keywords
The Involvement of Cytochrome c Oxidase in Mitochondrial Fusion in Primary Cultures of Neonatal Rat Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2018 at "Cardiovascular Toxicology"
DOI: 10.1007/s12012-018-9447-1
Abstract: Cytochrome c oxidase (CCO) is a copper-dependent enzyme of mitochondrial respiratory chain. In pressure overload-induced cardiac hypertrophy, copper level and CCO activity are both depressed, along with disturbance in mitochondrial fusion and fission dynamics. Copper… read more here.
Keywords: cco; mitochondrial fusion; copper; cco activity ... See more keywords
Autophagy Inhibition Reduces Irradiation-Induced Subcortical White Matter Injury Not by Reducing Inflammation, but by Increasing Mitochondrial Fusion and Inhibiting Mitochondrial Fission
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Neurobiology"
DOI: 10.1007/s12035-021-02653-x
Abstract: Radiotherapy is an effective tool in the treatment of malignant brain tumors, but irradiation-induced late-onset toxicity remains a major problem. The purpose of this study was to investigate if genetic inhibition of autophagy has an… read more here.
Keywords: mitochondrial fusion; white matter; subcortical white; irradiation ... See more keywords
Mitochondrial Fusion Proteins: A Tale of Two Membranes
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.467
Abstract: Dynamins are a class of GTPase enzymes responsible for the fusion, fission, and vesiculation of cellular lipid membranes throughout the cell. The dynamin-like proteins Optic Atrophy 1 (Opa1) and Mitofusin (Mfn) 1 and 2 are… read more here.
Keywords: proteins tale; fusion proteins; tale two; mitochondrial fusion ... See more keywords
WBSCR16 Is a Guanine Nucleotide Exchange Factor Important for Mitochondrial Fusion.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.06.090
Abstract: Regulated inter-mitochondrial fusion/fission is essential for maintaining optimal mitochondrial respiration and control of apoptosis and autophagy. In mammals, mitochondrial fusion is controlled by outer membrane GTPases MFN1 and MFN2 and by inner membrane (IM) GTPase… read more here.
Keywords: important mitochondrial; nucleotide exchange; guanine nucleotide; exchange factor ... See more keywords
Mitochondrial respiratory chain damage and mitochondrial fusion disorder are involved in liver dysfunction of fluoride-induced mice.
Sign Up to like & getrecommendations! Published in 2019 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2019.125099
Abstract: Our previous study showed that excessive fluoride (F) intake can induce liver dysfunction. The aim of this study was to investigate the mechanisms of F-induced mitochondrial damage resulting in liver dysfunction. Damaged mitochondrial ultrastructure and… read more here.
Keywords: mitochondrial respiratory; respiratory chain; dysfunction; liver dysfunction ... See more keywords
κ-opioid receptor activation promotes mitochondrial fusion and enhances myocardial resistance to ischemia and reperfusion injury via STAT3-OPA1 pathway.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.172987
Abstract: Mitochondrial dynamics, determining mitochondrial morphology, quality and abundance, have recently been implicated in myocardial ischemia and reperfusion (MI/R) injury. The roles of κ-opioid receptor activation in cardioprotection have been confirmed in our previous studies, while… read more here.
Keywords: receptor activation; opioid receptor; mitochondrial fusion; receptor ... See more keywords
Polydatin protects SH-SY5Y in models of Parkinson's disease by promoting Atg5-mediated but parkin-independent autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2020.104671
Abstract: Parkinson's disease (PD), the second most common chronic neurodegenerative disorder, broadly remains incurable. Both genetic susceptibility and exposure to deleterious environmental stimuli contribute to dopaminergic neuron degeneration in the substantia nigra. Hence, reagents that can… read more here.
Keywords: disease; mitochondrial fusion; autophagy; polydatin protects ... See more keywords
Fibroblast growth factor 18 exerts anti‐osteoarthritic effects through PI3K‐AKT signaling and mitochondrial fusion and fission
Sign Up to like & getrecommendations! Published in 2019 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2018.09.026
Abstract: &NA; Osteoarthritis (OA) is a degenerative disease characterized by progressive loss of cartilage, osteophyte formation and subchondral bone sclerosis. Although some animal experiments have reported that fibroblast growth factor 18 (FGF18) attenuates cartilage degradation, the… read more here.
Keywords: akt signaling; fgf18; pi3k akt; mitochondrial fusion ... See more keywords