Signal transducer and activator of transcription 5a (STAT5a) represses mitochondrial gene expression through direct binding to mitochondrial DNA.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.04.152
Abstract: Signal transducer and activator of transcription (STAT) proteins are latent cytoplasmic transcription factors essential for cytokine signaling. Our previous study showed that interleukin-3 (IL-3) induced STAT5 translocation to mitochondria and binding to mitochondrial DNA (mtDNA)… read more here.
Keywords: transcription; mitochondrial gene; stat5a; gene expression ... See more keywords
Physicochemical characterization and targeting performance of triphenylphosphonium nano-polyplexes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2020.113873
Abstract: Abstract Mitochondrial gene therapy can be seen as a promising tool and a revolutionary approach towards mitochondrial diseases arising from mitochondrial DNA mutations. To pursue this goal, the mitochondria-targeted polycation polyethylenimine (PEI)/triphenylphosphonium (TPP) conjugate has… read more here.
Keywords: characterization targeting; mitochondrial gene; gene therapy; physicochemical characterization ... See more keywords
Ancient mitochondrial gene transfer between fungi and the orchids.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular biology and evolution"
DOI: 10.1093/molbev/msz198
Abstract: The mitochondrial genomes (mitogenomes) of plants are known to incorporate and accumulate DNA from intra- and extracellular donors. Despite the intimate relationships formed between flowing plants (angiosperms) and fungi, lengthy fungal-like sequence has not been… read more here.
Keywords: ancient mitochondrial; mitochondrial gene; angiosperm mitogenomes; transfer ... See more keywords
Correlation between hepatic oxidative damage and clinical severity and mitochondrial gene sequencing results in biliary atresia
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology Research"
DOI: 10.1111/hepr.13324
Abstract: To assess the level of hepatic oxidative damage and its correlation with clinical severity in biliary atresia (BA), and to understand BA mitochondrial gene sequencing. read more here.
Keywords: oxidative damage; mitochondrial gene; biliary atresia; clinical severity ... See more keywords
Maternal and Fetal Mitochondrial Gene Dysregulation in Hypertensive Disorders of Pregnancy.
Sign Up to like & getrecommendations! Published in 2023 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00005.2023
Abstract: Mitochondrial dysfunction has been implicated in pregnancy-induced hypertension (PIH). The role of mitochondrial gene dysregulation in PIH, and consequences for maternal-fetal interactions, remain elusive. Here, we investigated mitochondrial gene expression and dysregulation in maternal and… read more here.
Keywords: mitochondrial gene; gene dysregulation; maternal fetal; fetal mitochondrial ... See more keywords
Polymorphic duplicate genes and persistent non-coding sequences reveal heterogeneous patterns of mitochondrial DNA loss in salamanders
Sign Up to like & getrecommendations! Published in 2017 at "BMC Genomics"
DOI: 10.1186/s12864-017-4358-2
Abstract: BackgroundMitochondria are the site of the citric acid cycle and oxidative phosphorylation (OXPHOS). In metazoans, the mitochondrial genome is a small, circular molecule averaging 16.5 kb in length. Despite evolutionarily conserved gene content, metazoan mitochondrial genomes… read more here.
Keywords: duplication; duplicate; mitochondrial gene; dna loss ... See more keywords
Mitochondrial gene sequence variants in children with severe malaria anaemia with or without lactic acidosis: a case control study
Sign Up to like & getrecommendations! Published in 2018 at "Malaria Journal"
DOI: 10.1186/s12936-018-2618-5
Abstract: BackgroundEvolutionary pressure by Plasmodium falciparum malaria is known to have favoured a large number of human gene adaptations, but there is surprisingly little investigation of the effect of malaria on human mitochondrial sequence variation. Plasmodium… read more here.
Keywords: acidosis; lactic acidosis; mitochondrial gene; anaemia ... See more keywords
Mitochondrial Gene Diversity and Host Specificity of Isospora in Passerine Birds
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2022.847030
Abstract: Isospora infections are common in both wild and captive passerine species. Many bird species have been shown to have co-evolved with a particular species of Isospora. Disease can range from subclinical to severe and fatal,… read more here.
Keywords: mitochondrial gene; host specificity; specificity isospora; passerine ... See more keywords
First Report on Mitochondrial Gene Rearrangement in Non-Biting Midges, Revealing a Synapomorphy in Stenochironomus Kieffer (Diptera: Chironomidae)
Sign Up to like & getrecommendations! Published in 2022 at "Insects"
DOI: 10.3390/insects13020115
Abstract: Simple Summary Gene rearrangement is an additional type of data to support relationships of taxa, with rearrangement synapomorphies identified across multiple orders and at many different taxonomic levels. The concept to use mitochondrial gene rearrangements… read more here.
Keywords: mitochondrial gene; gene; gene rearrangement; chironomidae ... See more keywords
Genetic Polymorphism and Phylogenetics of Aedes aegypti from Sudan Based on ND4 Mitochondrial Gene Variations
Sign Up to like & getrecommendations! Published in 2022 at "Insects"
DOI: 10.3390/insects13121144
Abstract: Simple Summary Arthropod-borne viruses (arboviruses) place a heavy social and economic burden on society by infecting millions of people and causing widespread animal and human sickness. These viruses are often transmitted to their vertebrate hosts… read more here.
Keywords: aedes aegypti; mitochondrial gene; genetic polymorphism; gene ... See more keywords
Peptides vs. Polymers: Searching for the Most Efficient Delivery System for Mitochondrial Gene Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14040757
Abstract: Together with the nucleus, the mitochondrion has its own genome. Mutations in mitochondrial DNA are responsible for a variety of disorders, including neurodegenerative diseases and cancer. Current therapeutic approaches are not effective. In this sense,… read more here.
Keywords: system; gene; mitochondrial gene; gene therapy ... See more keywords