Mitochondrial GPT2 plays a pivotal role in metabolic adaptation to the perturbation of mitochondrial glutamine metabolism
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DOI: 10.1038/s41388-019-0751-4
Abstract: Cancer cells exhibit metabolic dependence on mitochondrial glutamine metabolism that provides them with the substrates required for rapid proliferation. Despite the extensive efforts to target this glutamine addiction for therapeutic purposes, the adaptive metabolic responses… read more here.
Keywords: mitochondrial glutamine; glutamine metabolism; inhibition; gpt2 ... See more keywords