Genetic variation in the mitochondrial glycerol-3-phosphate acyltransferase is associated with liver injury.
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DOI: 10.1002/hep.32038
Abstract: Most of the genetic basis of chronic liver disease remains undiscovered. To identify novel genetic loci that modulate the risk of liver injury, we performed genome-wide association studies (GWAS) on circulating levels of alanine aminotransferase… read more here.
Keywords: liver injury; liver disease; gpam; mitochondrial glycerol ... See more keywords
Metformin’s Therapeutic Efficacy in the Treatment of Diabetes Does Not Involve Inhibition of Mitochondrial Glycerol Phosphate Dehydrogenase
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DOI: 10.2337/db20-1143
Abstract: Mitochondrial glycerol phosphate dehydrogenase (mGPD) is the rate-limiting enzyme of the glycerol phosphate redox shuttle. It was recently claimed that metformin, a first-line drug used for the treatment of type 2 diabetes, inhibits liver mGPD… read more here.
Keywords: phosphate dehydrogenase; metformin; mitochondrial glycerol; glycerol phosphate ... See more keywords
308-OR: Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Accelerates the Progression of Diabetic Glomerular Pathology
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DOI: 10.2337/db20-308-or
Abstract: Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease with limited therapeutic options. Although dysfunction of podocytes has been proved to critically associated with DKD, the mechanism underlying remains unclear. Here we… read more here.
Keywords: glomerular pathology; phosphate dehydrogenase; pathology; mitochondrial glycerol ... See more keywords