Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H2O2 emission during impaired oxidative phosphorylation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12405
Abstract: Muscle wasting and weakness in Duchenne muscular dystrophy (DMD) causes severe locomotor limitations and early death due in part to respiratory muscle failure. Given that current clinical practice focuses on treating secondary complications in this… read more here.
Keywords: elevated mitochondrial; muscular dystrophy; mitochondrial h2o2; h2o2 emission ... See more keywords
In situ fluorescence imaging reveals that mitochondrial H2O2 mediates lysosomal dysfunction in depression.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc00431c
Abstract: We constructed two fluorescent probes for monitoring H2O2 in the mitochondria and lysosomes. Fluorescence imaging reveals that mitochondrial H2O2 mediates reduced GCase activity in lysosomes in the brains of mice with depression. This work provides… read more here.
Keywords: reveals mitochondrial; depression; fluorescence imaging; mitochondrial h2o2 ... See more keywords