NIPSNAP protein family emerges as a sensor of mitochondrial health
Sign Up to like & getrecommendations! Published in 2021 at "BioEssays"
DOI: 10.1002/bies.202100014
Abstract: Since their discovery over two decades ago, the molecular and cellular functions of the NIPSNAP family of proteins (NIPSNAPs) have remained elusive until recently. NIPSNAPs interact with a variety of mitochondrial and cytoplasmic proteins. They… read more here.
Keywords: nipsnap protein; mitochondrial health; protein family; health ... See more keywords
Mitochondrial health and muscle plasticity after spinal cord injury
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Applied Physiology"
DOI: 10.1007/s00421-018-4039-0
Abstract: Mitochondria are responsible for aerobic respiration and large-scale ATP production in almost all cells of the body. Their function is decreased in many neurodegenerative and cardiovascular disease states, in metabolic disorders such as type II… read more here.
Keywords: skeletal muscle; mitochondrial health; muscle; cord injury ... See more keywords
A Mitochondrial Health Index Sensitive to Mood and Caregiving Stress
Sign Up to like & getrecommendations! Published in 2018 at "Biological psychiatry"
DOI: 10.1016/j.biopsych.2018.01.012
Abstract: BACKGROUND Chronic life stress, such as the stress of caregiving, can promote pathophysiology, but the underlying cellular mechanisms are not well understood. Chronic stress may induce recalibrations in mitochondria leading to changes either in mitochondrial… read more here.
Keywords: index; caregiving stress; mitochondrial health; mood ... See more keywords
Targeting Energy Pathways in Kidney Disease: The Roles of Sirtuins, AMPK, and PGC1α.
Sign Up to like & getrecommendations! Published in 2020 at "Kidney international"
DOI: 10.1016/j.kint.2020.09.037
Abstract: The kidney has extraordinary metabolic demands to sustain the active transport of solutes that is critical to renal filtration and clearance. Mitochondrial health is vital to meet those demands and maintain renal fitness. Decades of… read more here.
Keywords: mitochondrial health; pgc1; disease; targeting energy ... See more keywords
Sulfide-quinone oxidoreductase is required for cysteine synthesis and indispensable to mitochondrial health.
Sign Up to like & getrecommendations! Published in 2021 at "Redox biology"
DOI: 10.1016/j.redox.2021.102169
Abstract: Mitochondrial dysfunction is related to common age-related disorders, including neurodegenerative diseases, metabolic syndrome, and carcinogenesis. Therefore, maintaining the functionality and integrity of mitochondria is important for human health. Herein, we found that sulfide:quinone oxidoreductase (Sqr),… read more here.
Keywords: quinone oxidoreductase; mitochondrial health; sulfide quinone; health ... See more keywords
Mitochondrial health maintenance in axons.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Society transactions"
DOI: 10.1042/bst20170023
Abstract: Neurons are post-mitotic cells that must function throughout the life of an organism. The high energetic requirements and Ca2+ spikes of synaptic transmission place a burden on neuronal mitochondria. The removal of older mitochondria and… read more here.
Keywords: mitochondrial health; health maintenance; maintenance; maintenance axons ... See more keywords
Dolutegravir-containing HIV therapy reversibly alters mitochondrial health and morphology in cultured human fibroblasts and peripheral blood mononuclear cells
Sign Up to like & getrecommendations! Published in 2022 at "AIDS"
DOI: 10.1097/qad.0000000000003369
Abstract: Objectives: Given the success of combination antiretroviral therapy (cART) in treating HIV viremia, drug toxicity remains an area of interest in HIV research. Despite newer integrase strand transfer inhibitors (InSTIs), such as dolutegravir (DTG) and… read more here.
Keywords: health; mitochondrial health; mononuclear cells; blood mononuclear ... See more keywords
Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13662
Abstract: Osteoarthritis (OA) is the most common age‐related joint disorder with no effective therapy. According to the World Health Organization, OA affects over 500 million people and is characterized by degradation of cartilage and other joint… read more here.
Keywords: health; mitochondrial health; mitophagy mitochondrial; cartilage degeneration ... See more keywords
High-Throughput Phenotypic Assay for Compounds That Influence Mitochondrial Health Using iPSC-Derived Human Neurons
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DOI: 10.1177/24725552211000671
Abstract: There is a critical need to develop high-throughput assays to identify compounds that offer therapy for individuals suffering from neurodegenerative diseases. Most brain disorders, including neurodegenerative diseases, share the common neuropathology of mitochondria dysfunction, which… read more here.
Keywords: human neurons; assay compounds; throughput; mitochondrial health ... See more keywords
Physical Exercise: A Novel Tool to Protect Mitochondrial Health
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.660068
Abstract: Mitochondrial dysfunction is a crucial contributor to heart diseases. Alterations in energetic metabolism affect crucial homeostatic processes, such asATP production, the generation of reactive oxygen species, and the release of pro-apoptotic factors, associated with metabolic… read more here.
Keywords: mitochondrial health; physical exercise; health physical; exercise ... See more keywords