Laminar shear stress promotes mitochondrial homeostasis in endothelial cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26375
Abstract: Vascular endothelial cells (ECs) are constantly subjected to flow‐induced shear stress that is crucial for endothelial functions. Laminar shear stress (LSS) exerts atheroprotection to ECs. Mitochondrial homeostasis is essential for cellular survival. However, the effects… read more here.
Keywords: homeostasis; shear stress; ecs; mitochondrial homeostasis ... See more keywords
Miro1 regulates mitochondrial homeostasis and meiotic resumption of mouse oocyte
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30890
Abstract: Miro1, a mitochondrial Rho GTPase1, is a kind of mitochondrial outer membrane protein involved in the regulation of mitochondrial anterograde transport and its subcellular distribution. Mitochondria influence reproductive processes of mammals in some aspects. Mitochondria… read more here.
Keywords: mitochondrial homeostasis; miro1 regulates; mouse oocyte; maturation ... See more keywords
The role of SIRT3-mediated mitochondrial homeostasis in osteoarthritis
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03497-9
Abstract: Osteoarthritis is the most common degenerative joint disease and causes major pain and disability in adults. It has been reported that mitochondrial dysfunction in chondrocytes is associated with osteoarthritis. Sirtuins are a family of nicotinamide… read more here.
Keywords: homeostasis; mediated mitochondrial; osteoarthritis; mitochondrial homeostasis ... See more keywords
A pair of transporters controls mitochondrial Zn2+ levels to maintain mitochondrial homeostasis.
Sign Up to like & getrecommendations! Published in 2021 at "Protein & cell"
DOI: 10.1007/s13238-021-00881-4
Abstract: Zn2+ is required for the activity of many mitochondrial proteins, which regulate mitochondrial dynamics, apoptosis and mitophagy. However, it is not understood how the proper mitochondrial Zn2+ level is achieved to maintain mitochondrial homeostasis. Using… read more here.
Keywords: transporters controls; mitochondrial homeostasis; maintain mitochondrial; mitochondrial zn2 ... See more keywords
ATP synthase inhibitory factor subunit 1 regulates islet β-cell function via repression of mitochondrial homeostasis
Sign Up to like & getrecommendations! Published in 2021 at "Laboratory Investigation"
DOI: 10.1038/s41374-021-00670-x
Abstract: Mitochondrial homeostasis is crucial for the function of pancreatic β-cells. ATP synthase inhibitory factor subunit 1 (IF1) is a mitochondrial protein interacting with ATP synthase to inhibit its enzyme activity. IF1 may also play a… read more here.
Keywords: atp synthase; inhibitory factor; mitochondrial homeostasis; function ... See more keywords
FoxO transcription factors in mitochondrial homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Journal"
DOI: 10.1042/bcj20210777
Abstract: Mitochondria play essential roles in cellular energetics, biosynthesis, and signaling transduction. Dysfunctional mitochondria have been implicated in different diseases such as obesity, diabetes, cardiovascular disease, nonalcoholic fatty liver disease, neurodegenerative disease, and cancer. Mitochondrial homeostasis… read more here.
Keywords: homeostasis; factors mitochondrial; foxo transcription; transcription factors ... See more keywords
CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1695398
Abstract: ABSTRACT CASP9 (caspase 9) is a well-known initiator caspase which triggers intrinsic apoptosis. Recent studies also suggest various non-apoptotic roles of CASP9, including macroautophagy/autophagy regulation. However, the involvement of CASP9 in autophagy and its molecular… read more here.
Keywords: caspase; casp9; mitochondrial homeostasis; maturation ... See more keywords
CDC25C is a prognostic biomarker and correlated with mitochondrial homeostasis in pancreatic adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2078940
Abstract: ABSTRACT Pancreatic adenocarcinoma (PAAD) is a common digestive tract malignant tumor with an extremely poor prognosis. The survival and prognosis may significantly improve if it is diagnosed early. Therefore, identifying biomarkers for early diagnosis is… read more here.
Keywords: mitochondrial homeostasis; cdc25c; pancreatic adenocarcinoma; paad ... See more keywords
Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasis.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000375
Abstract: BACKGROUND AIMS Nonalcoholic steatohepatitis (NASH), characterized by inflammation and fibrosis, is emerging as a leading etiology of hepatocellular carcinoma (HCC). Lipidomics analyses in the liver have shown that the levels of polyunsaturated phosphatidylcholine (PC) are… read more here.
Keywords: lpcat3; mitochondrial homeostasis; membrane; phospholipid remodeling ... See more keywords
Yersinia pestis-Induced Mitophagy That Balances Mitochondrial Homeostasis and mROS-Mediated Bactericidal Activity
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DOI: 10.1128/spectrum.00718-22
Abstract: Y. pestis, the pathogen of plague, also known as the “Black Death,” has caused millions of deaths throughout history. This study reports that Y. pestis infection induces mitochondrial fragmentation and abnormal mROS accumulation, and releases… read more here.
Keywords: pestis; pestis induced; infection; mitochondrial homeostasis ... See more keywords
Ataxia Telangiestasia Mutated (ATM) Inhibition Disrupts Nuclear And Mitochondrial Homeostasis In Pediatric Nonalcoholic Fatty Liver Disease (PNAFLD)
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DOI: 10.1152/physiol.2023.38.s1.5735159
Abstract: BACKGROUND: The pathophysiology of PNAFLD is important to understand in order to improve outcomes. Integration of critical components including metabolic stress, inflammation, organelle function, and DNA damage and repair should be particularly critical for this… read more here.
Keywords: fatty liver; growth; mitochondrial homeostasis; physiology ... See more keywords