Protein translocation in mitochondria: Sorting out the Toms, Tims, Pams, Sams and Mia.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS letters"
DOI: 10.1002/1873-3468.14614
Abstract: Mitochondria contain 902 (yeast) to 1.136 (mouse, humans) verified proteins. Except for a very small number of mitochondrially encoded core components of the respiratory chain, mitochondrial proteins are encoded by nuclear genes and synthesized in… read more here.
Keywords: protein translocation; sorting toms; import; mitochondrial import ... See more keywords
MitoCPR: a novel protective mechanism in response to mitochondrial protein import stress
Sign Up to like & getrecommendations! Published in 2018 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.1093/abbs/gmy098
Abstract: Mitochondria are dynamic, double-membrane-bound organelle of eukaryotic cells that have evolved to function in a wide range of cellular processes. They are responsible for oxidative phosphorylation (OXPHOS), producing energy and metabolites, regulating apoptosis and maintaining… read more here.
Keywords: protein; mitochondrial protein; protein import; mitochondrial import ... See more keywords
Mitochondrial import, health and mtDNA copy number variability seen when using type II and type V CRISPR effectors
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.248468
Abstract: ABSTRACT Current methodologies for targeting the mitochondrial genome for research and/or therapy development in mitochondrial diseases are restricted by practical limitations and technical inflexibility. A molecular toolbox for CRISPR-mediated mitochondrial genome editing is desirable, as… read more here.
Keywords: copy number; crispr; mitochondrial import; crispr effectors ... See more keywords