Loss of mitochondrial Chchd10 or Chchd2 in zebrafish leads to an ALS‐like phenotype and Complex I deficiency independent of the mitochondrial integrated stress response
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DOI: 10.1002/dneu.22909
Abstract: Mutations in CHCHD10 and CHCHD2, encoding two paralogous mitochondrial proteins, have been identified in cases of amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Parkinson's disease. Their role in disease is unclear, though both have been… read more here.
Keywords: chchd10; chchd10 chchd2; chchd2 zebrafish; mitochondrial integrated ... See more keywords
Hepatic Fis1 regulates mitochondrial integrated stress response and improves metabolic homeostasis
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DOI: 10.1172/jci.insight.150041
Abstract: Mitophagy and mitochondrial integrated stress response (ISR) are 2 primary protective mechanisms to maintain functional mitochondria. Whether these 2 processes are coordinately regulated remains unclear. Here we show that mitochondrial fission 1 protein (Fis1), which… read more here.
Keywords: fis1; stress response; mitochondrial integrated; integrated stress ... See more keywords