Volumetric Engineered 3D Drug Reservoir Against Diabetic Implant Infection via Cuproptosis‐Like Bacterial Death and Hunger‐Triggered Maintenance of Mitochondrial Integrity
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202506554
Abstract: Implant‐associated infections in diabetic patients pose critical challenges due to immune‐metabolic dysregulation that exacerbates biofilm persistence and tissue damage. This study introduces a “dimensional rise” strategy integrating 3D‐printed porous titanium frameworks with micro‐nano hierarchical structures… read more here.
Keywords: drug; cuproptosis like; mitochondrial integrity; drug reservoir ... See more keywords
Regulatory Role of Tubulin Beta 1 in Oocyte Endoplasmic Reticulum Stress and Mitochondrial Integrity via Transforming Growth Factor‐β1 Signaling Pathway in Mice
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.70042
Abstract: Enhancing the developmental competence and quality of oocytes cultured in vitro remains challenging, in part due to limited understanding of the structural and molecular regulators of oocyte maturation. Microtubules, as key components of the cytoskeleton,… read more here.
Keywords: role; stress; tubb1; mitochondrial integrity ... See more keywords
GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function
Sign Up to like & getrecommendations! Published in 2020 at "Cell Metabolism"
DOI: 10.1016/j.cmet.2020.05.001
Abstract: Summary Astrocytes represent central regulators of brain glucose metabolism and neuronal function. They have recently been shown to adapt their function in response to alterations in nutritional state through responding to the energy state-sensing hormones… read more here.
Keywords: oxidation; glp; function; glp receptor ... See more keywords
Mic60 is essential to maintain mitochondrial integrity and to prevent encephalomyopathy.
Sign Up to like & getrecommendations! Published in 2023 at "Brain pathology"
DOI: 10.1111/bpa.13157
Abstract: Mitochondrial encephalomyopathies (ME) are frequently associated with mutations of mitochondrial DNA, but the pathogenesis of a subset of ME (sME) remains elusive. Here we report that haploinsufficiency of a mitochondrial inner membrane protein, Mic60, causes… read more here.
Keywords: mic60; essential maintain; mic60 essential; maintain mitochondrial ... See more keywords
TbLpn, a key enzyme in lipid droplet formation and phospholipid metabolism, is essential for mitochondrial integrity and growth of Trypanosoma brucei
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DOI: 10.1111/mmi.13976
Abstract: Mammalian phosphatidic acid phosphatases, also called lipins, show high amino acid sequence identity to Saccharomyces cerevisiae Pah1p and catalyze the dephosphorylation of phosphatidic acid (PA) to diacylglycerol. Both the substrate and product of the reaction… read more here.
Keywords: formation; tblpn; mitochondrial integrity; trypanosoma brucei ... See more keywords
The mitochondrial membrane protein FgLetm1 regulates mitochondrial integrity, production of endogenous reactive oxygen species and mycotoxin biosynthesis in Fusarium graminearum.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular plant pathology"
DOI: 10.1111/mpp.12633
Abstract: Deoxynivalenol (DON) is a mycotoxin produced in cereal crops infected with Fusarium graminearum. DON poses a serious threat to human and animal health, and is a critical virulence factor. Various environmental factors, including reactive oxygen… read more here.
Keywords: biosynthesis; fgletm1; production; graminearum ... See more keywords
Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Experimental Biology"
DOI: 10.1242/jeb.200410
Abstract: ABSTRACT Mitochondria are important to cellular homeostasis, but can become a dangerous liability when cells recover from hypoxia. Anoxia-tolerant freshwater turtles show reduced mitochondrial respiratory capacity and production of reactive oxygen species (ROS) after prolonged… read more here.
Keywords: mitochondrial respiratory; heart; anoxia; cold acclimation ... See more keywords
Galanin Coordinates Macrophage-Associated Fibro-Inflammatory Response and Mitochondrial Integrity in Myocardial Infarction Reperfusion Injury
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25116211
Abstract: Myocardial infarction activates an intense fibro-inflammatory reaction that is essential for cardiac remodeling and heart failure (HF). Bioactive peptide galanin plays a critical role in regulating cardiovascular homeostasis; however, its specific functional relevance in post-infarction… read more here.
Keywords: galanin; fibro inflammatory; reperfusion; infarction ... See more keywords