Synthesis, mitochondrial localization of fluorescent derivatives of cinnamamide as anticancer agents.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.03.001
Abstract: Mitochondria are considered as a therapeutic target for new drug design toward all kinds of cancer. Hence in order to enhance the dosage in mitochondrial fraction of cinnamamides, the mitochondria-targeted derivatives were designed by the… read more here.
Keywords: fluorescent derivatives; synthesis mitochondrial; derivatives cinnamamide; localization fluorescent ... See more keywords
Two sides of a coin: Physiological significance and molecular mechanisms for damage-induced mitochondrial localization of PINK1 and Parkin
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Research"
DOI: 10.1016/j.neures.2020.03.009
Abstract: In 1998, PARKIN was reported as a causal gene for hereditary recessive Parkinsonism by Kitada, Mizuno, Hattori, and Shimizu et al. Later in 2004, PINK1 was also reported as a causal gene for hereditary recessive… read more here.
Keywords: localization pink1; two sides; pink1; pink1 parkin ... See more keywords
Tid1-S regulates the mitochondrial localization of EGFR in non-small cell lung carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Oncogenesis"
DOI: 10.1038/oncsis.2017.62
Abstract: The epidermal growth factor receptor (EGFR) is the major driver of non-small cell lung carcinoma (NSCLC). Mitochondrial accumulation of EGFR has been shown to promote metastasis in NSCLC, yet little is known about how the… read more here.
Keywords: egfr; localization egfr; tid1; non small ... See more keywords
Toxicological Implications of Mitochondrial Localization of CYP2E1.
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology research"
DOI: 10.1039/c7tx00020k
Abstract: Cytochrome P450 2E1 (CYP2E1) metabolizes an extensive array of pollutants, drugs, and other small molecules, often resulting in bioactivation to reactive metabolites. Therefore, it is unsurprising that it has been the subject of decades of… read more here.
Keywords: cyp2e1; toxicological implications; localization cyp2e1; implications mitochondrial ... See more keywords
Sequences flanking the transmembrane segments facilitate mitochondrial localization and membrane fusion by mitofusin
Sign Up to like & getrecommendations! Published in 2017 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1708782114
Abstract: Significance Mitochondria constantly connect through membrane fusion. The merging of the outer mitochondrial membrane requires mitofusin (MFN) proteins. MFN is a membrane-anchored GTPase, but whether it is sufficient to achieve fusion, and if so how,… read more here.
Keywords: mfn; transmembrane segments; membrane fusion; fusion ... See more keywords
MitoMiner v4.0: an updated database of mitochondrial localization evidence, phenotypes and diseases
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky1072
Abstract: Abstract Increasing numbers of diseases are associated with mitochondrial dysfunction. This is unsurprising given mitochondria have major roles in bioenergy generation, signalling, detoxification, apoptosis and biosynthesis. However, fundamental questions of mitochondrial biology remain, including: which… read more here.
Keywords: evidence; phenotypes diseases; localization evidence; localization ... See more keywords
Dexmedetomidine reduces enteric glial cell injury induced by intestinal ischaemia-reperfusion injury through mitochondrial localization of TERT.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cellular and molecular medicine"
DOI: 10.1111/jcmm.17261
Abstract: This study was performed to uncover the effects of dexmedetomidine on oxidative stress injury induced by mitochondrial localization of telomerase reverse transcriptase (TERT) in enteric glial cells (EGCs) following intestinal ischaemia-reperfusion injury (IRI) in rat… read more here.
Keywords: dexmedetomidine; mitochondrial localization; localization tert; injury ... See more keywords
Mitochondrial localization and moderated activity are key to murine erythroid enucleation.
Sign Up to like & getrecommendations! Published in 2021 at "Blood advances"
DOI: 10.1182/bloodadvances.2021004259
Abstract: Mammalian red blood cells (RBCs), which primarily contain hemoglobin, exemplify an elaborate maturation process, with the terminal steps of RBC generation involving extensive cellular remodeling. This encompasses alterations of cellular content through distinct stages of… read more here.
Keywords: activity key; localization moderated; activity; enucleation ... See more keywords