Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during aging
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13583
Abstract: Sarcopenia is one of the main factors contributing to the disability of aged people. Among the possible molecular determinants of sarcopenia, increasing evidences suggest that chronic inflammation contributes to its development. However, a key unresolved… read more here.
Keywords: inflammation; lysosomal homeostasis; muscle; atrophy ... See more keywords
Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aam9080
Abstract: Human-derived neurons provide the answers Pathways involved in energy metabolism and removal of cellular debris by lysosomes play an important role in protecting our brain from degeneration in Parkinson's disease. Burbulla et al. identified a… read more here.
Keywords: dysfunction; lysosomal dysfunction; mitochondrial lysosomal; parkinson disease ... See more keywords
Psychotropic Drugs Show Anticancer Activity by Disrupting Mitochondrial and Lysosomal Function
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.562196
Abstract: Background and Purpose: Drug repositioning is a promising strategy for discovering new therapeutic strategies for cancer therapy. We investigated psychotropic drugs for their antitumor activity because of several epidemiological studies reporting lower cancer incidence in… read more here.
Keywords: death; mitochondrial lysosomal; cancer; cell ... See more keywords