Plasmodium Parasite Malate-Quinone Oxidoreductase Functionally Complements a Yeast Deletion Mutant of Mitochondrial Malate Dehydrogenase
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DOI: 10.1128/spectrum.00168-23
Abstract: We constructed a model organism to study the physiological role and function of P. falciparum malate-quinone oxidoreductase (PfMQO) in a yeast expression system. PfMQO is actively expressed in yeast mitochondria and functions in place of… read more here.
Keywords: malate quinone; mitochondrial malate; malate dehydrogenase; quinone oxidoreductase ... See more keywords
Ketogenic Diet Treatment of Defects in the Mitochondrial Malate Aspartate Shuttle and Pyruvate Carrier
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DOI: 10.3390/nu14173605
Abstract: The mitochondrial malate aspartate shuttle system (MAS) maintains the cytosolic NAD+/NADH redox balance, thereby sustaining cytosolic redox-dependent pathways, such as glycolysis and serine biosynthesis. Human disease has been associated with defects in four MAS-proteins (encoded… read more here.
Keywords: mitochondrial malate; aspartate shuttle; pyruvate carrier; treatment ... See more keywords