Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature21052
Abstract: The genome of pancreatic ductal adenocarcinoma (PDAC) frequently contains deletions of tumour suppressor gene loci, most notably SMAD4, which is homozygously deleted in nearly one-third of cases. As loss of neighbouring housekeeping genes can confer… read more here.
Keywords: cancer; collateral lethality; malic enzyme; mitochondrial malic ... See more keywords
Overexpression of the Mitochondrial Malic Enzyme Genes (malC and malD) Improved the Lipid Accumulation in Mucor circinelloides WJ11
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.919364
Abstract: Mucor circinelloides serves as a model organism to investigate the lipid metabolism in oleaginous microorganisms. It is considered as an important producer of γ-linolenic acid (GLA) that has vital medicinal benefits. In this study, we… read more here.
Keywords: mucor circinelloides; overexpression; lipid accumulation; mitochondrial malic ... See more keywords