An inventory of interactors of the human HSP60/HSP10 chaperonin in the mitochondrial matrix space
Sign Up to like & getrecommendations! Published in 2020 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-020-01080-6
Abstract: The HSP60/HSP10 chaperonin assists folding of proteins in the mitochondrial matrix space by enclosing them in its central cavity. The chaperonin forms part of the mitochondrial protein quality control system. It is essential for cellular… read more here.
Keywords: hsp10 chaperonin; hsp60 hsp10; chaperonin; mitochondrial matrix ... See more keywords
O2 affects mitochondrial functionality ex vivo
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2019.101152
Abstract: Mitochondria have originated in eukaryotic cells by endosymbiosis of a specialized prokaryote approximately 2 billion years ago. They are essential for normal cell function by providing energy through their role in oxidizing carbon substrates. Glutathione… read more here.
Keywords: functionality vivo; mitochondrial functionality; matrix; affects mitochondrial ... See more keywords
Suborganelle-Specific Protein Complex Analysis Enabled by in Vivo Cross-Linking Coupled with Proximal Labeling.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c01637
Abstract: The identification of the structure of protein complexes in the subcellular niche of cells is necessary to understand their diverse functions. In this study, we developed a suborganelle proteome labeling assisted in vivo cross-linking (SubPiXL)… read more here.
Keywords: mitochondrial matrix; cross linking; cross; vivo cross ... See more keywords
Mitochondrial matrix protein C14orf159 attenuates colorectal cancer metastasis by suppressing Wnt/β-catenin signalling.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of cancer"
DOI: 10.1038/s41416-021-01582-9
Abstract: BACKGROUND The mechanisms underlying metastasis of colorectal cancer (CRC) remain unclear. C14orf159 is a mitochondrial matrix protein converting D-glutamate to 5-oxo-D-proline. Other metabolic functions of C14orf159, especially on mitochondrial metabolism, and its contribution to CRC… read more here.
Keywords: matrix protein; metastasis; mitochondrial matrix; crc ... See more keywords
Solid-phase inclusion as a mechanism for regulating unfolded proteins in the mitochondrial matrix
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.abc7288
Abstract: Formation of solid-phase protein aggregates in mitochondria is associated with mitochondrial lipid metabolism. Proteostasis declines with age, characterized by the accumulation of unfolded or damaged proteins. Recent studies suggest that proteins constituting pathological inclusions in… read more here.
Keywords: unfolded proteins; solid phase; dump; mitochondrial matrix ... See more keywords
Inhibition of Mitochondrial Matrix Chaperones and Antiapoptotic Bcl-2 Family Proteins Empower Antitumor Therapeutic Responses.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-16-3424
Abstract: Rational therapeutic approaches based on synthetic lethality may improve cancer management. On the basis of a high-throughput drug screen, we provide preclinical proof of concept that targeting the mitochondrial Hsp90 chaperone network (mtHsp90) and inhibition… read more here.
Keywords: cancer; gamitrinib tpp; bcl family; mitochondrial matrix ... See more keywords
TMBIM5 loss of function alters mitochondrial matrix ion homeostasis and causes a skeletal myopathy
Sign Up to like & getrecommendations! Published in 2022 at "Life Science Alliance"
DOI: 10.26508/lsa.202201478
Abstract: TMBIM5 deficiency reduces mitochondrial K+/H+ exchange. Mutation of the channel pore in mice destabilizes the protein and results in increased embryonic lethality and a skeletal myopathy. Ion fluxes across the inner mitochondrial membrane control mitochondrial… read more here.
Keywords: mitochondrial matrix; function; loss; ion ... See more keywords
Integration of Eukaryotic Energy Metabolism: The Intramitochondrial and Cytosolic Energy States ([ATP]f/[ADP]f[Pi])
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105550
Abstract: Maintaining a robust, stable source of energy for doing chemical and physical work is essential to all living organisms. In eukaryotes, metabolic energy (ATP) production and consumption occurs in two separate compartments, the mitochondrial matrix… read more here.
Keywords: mitochondrial matrix; metabolism; energy metabolism; atp adp ... See more keywords
Precipitation of Inorganic Salts in Mitochondrial Matrix
Sign Up to like & getrecommendations! Published in 2020 at "Membranes"
DOI: 10.3390/membranes10050081
Abstract: In the mitochondrial matrix, there are insoluble, osmotically inactive complexes that maintain a constant pH and calcium concentration. In the present paper, we examine the properties of insoluble calcium and magnesium salts, such as phosphates,… read more here.
Keywords: salts mitochondrial; inorganic salts; mitochondrial matrix; precipitation inorganic ... See more keywords