The mitochondrial metabolic reprogramming agent trimetazidine as an ‘exercise mimetic’ in cachectic C26‐bearing mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12226
Abstract: Cancer cachexia is characterized by muscle depletion and exercise intolerance caused by an imbalance between protein synthesis and degradation and by impaired myogenesis. Myofibre metabolic efficiency is crucial so as to assure optimal muscle function.… read more here.
Keywords: metabolic reprogramming; muscle; trimetazidine; reprogramming agent ... See more keywords
Mitochondrial metabolic remodeling involved in the progression of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.484
Abstract: Pathogenesis of Alzheimer's disease (AD) affects not only central nervous system, but also peripheral glucose and lipid metabolism. We recently find the hepatic mitochondrial metabolic remodeling arises at the early stage of AD. For example,… read more here.
Keywords: metabolic remodeling; alzheimer disease; involved progression; remodeling involved ... See more keywords
The mitochondrial metabolic checkpoint in stem cell aging and rejuvenation
Sign Up to like & getrecommendations! Published in 2020 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2020.111254
Abstract: Stem cell aging contributes to aging-associated tissue degeneration and dysfunction. Recent studies reveal a mitochondrial metabolic checkpoint that regulates stem cell quiescence and maintenance, and dysregulation of the checkpoint leads to functional deterioration of aged… read more here.
Keywords: cell aging; stem cell; checkpoint; stem ... See more keywords
Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses.
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/circresaha.119.315833
Abstract: Rationale: A hallmark of chronic inflammatory disorders is persistence of pro-inflammatory macrophages in diseased tissues. In atherosclerosis this is associated with dyslipidemia and oxidative stress, but mechanisms linking these phenomena to macrophage activation remain incompletely… read more here.
Keywords: activation; metabolic reprogramming; mitochondrial metabolic; cd36 signaling ... See more keywords
Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Investigation"
DOI: 10.1172/jci120844
Abstract: Mammalian cells use a complex network of redox-dependent processes necessary to maintain cellular integrity during oxidative metabolism, as well as to protect against and/or adapt to stress. The disruption of these redox-dependent processes, including those… read more here.
Keywords: evidence targeting; metabolism; emerging evidence; cancer ... See more keywords
Mitochondrial and Metabolic Adaptations to Exercise-Induced Fluid Shear Stress in Endothelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "Exercise and Sport Sciences Reviews"
DOI: 10.1249/jes.0000000000000289
Abstract: Exercise-mediated hemodynamic flow confers mitochondrial remodeling and metabolic reprogramming in the vascular endothelial cell. Recent studies have greatly advanced our understanding of the central role of mitochondria on endothelial function. Here, we propose a hypothesis… read more here.
Keywords: adaptations exercise; metabolic adaptations; exercise induced; induced fluid ... See more keywords
Proteomic Analysis Suggests Altered Mitochondrial Metabolic Profile Associated With Diabetic Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.791700
Abstract: Diabetic cardiomyopathy (DbCM) occurs independently of cardiovascular diseases or hypertension, leading to heart failure and increased risk for death in diabetic patients. To investigate the molecular mechanisms involved in DbCM, we performed a quantitative proteomic… read more here.
Keywords: analysis; mitochondrial metabolic; diabetic cardiomyopathy; altered mitochondrial ... See more keywords
Mitochondrial metabolic reprogramming-mediated immunogenic cell death reveals immune and prognostic features of clear cell renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1146657
Abstract: Background Mitochondrial metabolic reprogramming (MMR)-mediated immunogenic cell death (ICD) is closely related to the tumor microenvironment (TME). Our purpose was to reveal the TME characteristics of clear cell renal cell carcinoma (ccRCC) by using them.… read more here.
Keywords: cell; mediated immunogenic; immunogenic cell; metabolic reprogramming ... See more keywords
Targeting Mitochondrial Metabolic Reprogramming as a Potential Approach for Cancer Therapy
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054954
Abstract: Abnormal energy metabolism is a characteristic of tumor cells, and mitochondria are important components of tumor metabolic reprogramming. Mitochondria have gradually received the attention of scientists due to their important functions, such as providing chemical… read more here.
Keywords: reprogramming potential; metabolic reprogramming; targeting mitochondrial; mitochondrial metabolic ... See more keywords
Targeting Mitochondrial Metabolic Dysfunction in Pulmonary Hypertension: Toward New Therapeutic Approaches?
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119572
Abstract: Pulmonary arterial hypertension (PAH) is a rare disease characterized by pulmonary vascular remodeling leading to right heart failure and death. To date, despite the three therapeutic approaches targeting the three major endothelial dysfunction pathways based… read more here.
Keywords: hypertension; approaches targeting; dysfunction; therapeutic approaches ... See more keywords