Targeting mitochondrial metabolism for metastatic cancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23436
Abstract: Primary tumors evolve metabolic mechanisms favoring glycolysis for adenosine triphosphate (ATP) generation and antioxidant defenses. In contrast, metastatic cells frequently depend on mitochondrial respiration and oxidative phosphorylation (OxPhos). This reliance of metastatic cells on OxPhos… read more here.
Keywords: mitochondrial metabolism; metastatic cancer; therapeutic agents; tumor ... See more keywords
Arsenite and methylarsonite inhibit mitochondrial metabolism and glucose-stimulated insulin secretion in INS-1 832/13 β cells
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Toxicology"
DOI: 10.1007/s00204-017-2074-y
Abstract: Growing evidence suggests that exposure to environmental contaminants contributes to the current diabetes epidemic. Inorganic arsenic (iAs), a drinking water and food contaminant, is one of the most widespread environmental diabetogens according to epidemiological studies.… read more here.
Keywords: insulin; gsis; exposure; mitochondrial metabolism ... See more keywords
Effects of Magnolia officinalis compatibility with Polygala tenuifolia on mitochondrial metabolism in rats’ liver based on bio-thermodynamics
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thermal Analysis and Calorimetry"
DOI: 10.1007/s10973-017-6197-4
Abstract: Polygala tenuifolia (Yuanzhi in Chinese) has gastrointestinal toxicity which can be significantly alleviated by Magnolia officinalis (Houpo in Chinese) due to the heat production of mitochondria based on our previous study. In this paper, we… read more here.
Keywords: compatibility; thermodynamics; metabolism; polygala tenuifolia ... See more keywords
Mitochondrial Metabolism Regulates Microtubule Acetylome and Autophagy Trough Sirtuin-2: Impact for Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0420-y
Abstract: Alterations in microtubule-dependent transport, mitochondrial dysfunction, and autophagic pathology are involved in neurodegeneration observed in sporadic Parkinson’s disease. However, the mechanistic link connecting these events remains elusive. We observed that NAD+ metabolism is altered in… read more here.
Keywords: parkinson; sporadic parkinson; mitochondrial metabolism; parkinson disease ... See more keywords
Reprogramming of mitochondrial metabolism by innate immunity.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2018.09.010
Abstract: The reprogramming of cellular metabolism has emerged as a major aspect of innate immune cell activation. Mitochondria, which are well known for their critical functions in cellular bioenergetics and metabolism, also serve innate immune purposes… read more here.
Keywords: metabolism; innate immune; innate immunity; mitochondrial metabolism ... See more keywords
Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice
Sign Up to like & getrecommendations! Published in 2021 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2021.111437
Abstract: Highlights • Transcriptomic changes are more similar within mutant mice that show either lengthened or shortened lifespan.• The major transcriptomic differences between long- and short-lived mice are in genes controlling mitochondrial metabolism.• Gene expression changes… read more here.
Keywords: mutant mice; normal ageing; long short; mitochondrial metabolism ... See more keywords
Mitochondrial Metabolism and Calcium Homeostasis in the development of NAFLD leading to Hepatocellular Carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Mitochondrion"
DOI: 10.1016/j.mito.2021.01.007
Abstract: Non-alcoholic fatty liver disease (NAFLD) is a metabolic syndrome characterized by excessive accumulation of hepatic lipid droplets. The disease progresses with steatosis as the premise for hepatocytic damage and tissue scarring, often culminating in hepatocellular… read more here.
Keywords: calcium; hepatocellular carcinoma; homeostasis; mitochondrial metabolism ... See more keywords
Biphasic Modeling of Mitochondrial Metabolism Dysregulation during Aging.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2017.06.005
Abstract: Organismal aging is classically viewed as a gradual decline of cellular functions and a systemic deterioration of tissues that leads to an increased mortality rate in older individuals. According to the prevailing theory, aging is… read more here.
Keywords: modeling mitochondrial; activity; biphasic modeling; mitochondrial metabolism ... See more keywords
Novel Mango Ginger Bioactive (2,4,6-Trihydroxy-3,5-diprenyldihydrochalcone) Inhibits Mitochondrial Metabolism in Combination with Avocatin B
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c04053
Abstract: Acute myeloid leukemia (AML) is an aggressive blood cancer with limited effective chemotherapy options and negative patient outcomes. Food-derived molecules such as avocatin B (Avo B), a fatty-acid oxidation (FAO) inhibitor, are promising novel therapeutics.… read more here.
Keywords: metabolism combination; mitochondrial metabolism; combination; trihydroxy diprenyldihydrochalcone ... See more keywords
Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07505-2
Abstract: Neutrophils are a vital component of immune protection, yet in cancer they may promote tumour progression, partly by generating reactive oxygen species (ROS) that disrupts lymphocyte functions. Metabolically, neutrophils are often discounted as purely glycolytic.… read more here.
Keywords: suppression; oxidative neutrophils; immune suppression; tumour elicited ... See more keywords
Mitochondrial metabolism promotes adaptation to proteotoxic stress
Sign Up to like & getrecommendations! Published in 2019 at "Nature chemical biology"
DOI: 10.1038/s41589-019-0291-9
Abstract: The mechanisms by which cells adapt to proteotoxic stress are largely unknown, but are key to understanding how tumor cells, particularly in vivo, are largely resistant to proteasome inhibitors. Analysis of cancer cell lines, mouse… read more here.
Keywords: proteasome inhibitor; stress; proteotoxic stress; mitochondrial metabolism ... See more keywords