Inactivation of cardiolipin synthase triggers changes in mitochondrial morphology
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.12948
Abstract: Mitochondrial tubular structures are maintained by a balance between membrane fusion and fission that is regulated by various factors, including Drp1 and mitofusin/fzo‐1. Here we report the role of cardiolipin (CL) synthase in the regulation… read more here.
Keywords: mitochondrial morphology; cardiolipin synthase; synthase; inactivation cardiolipin ... See more keywords
Monitoring the Effects of Pharmacological Reagents on Mitochondrial Morphology
Sign Up to like & getrecommendations! Published in 2018 at "Current Protocols in Cell Biology"
DOI: 10.1002/cpcb.45
Abstract: This protocol describes how to apply appropriate pharmacological controls to induce mitochondrial fusion or fission in studies of mitochondria morphology for four different mammalian cell types, HepG2 human liver hepatocellular carcinoma cells, MCF7 human breast… read more here.
Keywords: mitochondrial morphology; pharmacological reagents; morphology; monitoring effects ... See more keywords
Investigating Mitophagy and Mitochondrial Morphology In Vivo Using mito-QC: A Comprehensive Guide.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8873-0_41
Abstract: Autophagy evolved as a mechanism to sustain cellular homeostasis during instances of nutrient deprivation. Mounting evidence has also clarified that under basal and stress conditions, selective autophagy pathways can target the destruction of specific organelles.… read more here.
Keywords: mitochondrial morphology; vivo; mitophagy mitochondrial; investigating mitophagy ... See more keywords
Mitochondrial Assays Using Cardiac Stem Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9631-5_14
Abstract: Ischemic heart disease is the leading cause of death worldwide. Stem cell therapy to repair and regenerate the infarcted myocardium is a promising approach to address this unmet medical need. However, the poor survival of… read more here.
Keywords: mitochondrial morphology; cell; mitochondrial assays; stem ... See more keywords
Methods for imaging mammalian mitochondrial morphology: A prospective on MitoGraph.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2018.02.022
Abstract: Mitochondria are found in a variety of shapes, from small round punctate structures to a highly interconnected web. This morphological diversity is important for function, but complicates quantification. Consequently, early quantification efforts relied on various… read more here.
Keywords: imaging mammalian; mitochondrial morphology; methods imaging; mammalian mitochondrial ... See more keywords
3D neuronal mitochondrial morphology in axons, dendrites, and somata of the aging mouse hippocampus
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109509
Abstract: SUMMARY The brain’s ability to process complex information relies on the constant supply of energy through aerobic respiration by mitochondria. Neurons contain three anatomically distinct compartments—the soma, dendrites, and projecting axons—which have different energetic and… read more here.
Keywords: mitochondrial morphology; mouse hippocampus; morphology axons; neuronal mitochondrial ... See more keywords
Drp1 regulates mitochondrial morphology and cell proliferation in cutaneous squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2017.08.004
Abstract: BACKGROUND Dynamin-related protein 1 (Drp1) mediates mitochondrial fission. Recently, several studies have shown that Drp1 plays an important role in some cancers. However, little is known about Drp1 in cutaneous squamous cell carcinoma (SCC). OBJECTIVE… read more here.
Keywords: cell proliferation; drp1; cell; mitochondrial morphology ... See more keywords
Machine learning-based classification of mitochondrial morphology in primary neurons and brain
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-84528-8
Abstract: The mitochondrial network continually undergoes events of fission and fusion. Under physiologic conditions, the network is in equilibrium and is characterized by the presence of both elongated and punctate mitochondria. However, this balanced, homeostatic mitochondrial… read more here.
Keywords: machine learning; mitochondrial morphology; morphology; brain ... See more keywords
Mitochondrial morphology and cellular distribution are altered in SPG31 patients and are linked to DRP1 hyperphosphorylation
Sign Up to like & getrecommendations! Published in 2017 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddw425
Abstract: Hereditary spastic paraplegia, SPG31, is a rare neurological disorder caused by mutations in REEP1 gene encoding the microtubule-interacting protein, REEP1. The mechanism by which REEP1-dependent processes are linked with the disease is unclear. REEP1 regulates… read more here.
Keywords: mitochondrial morphology; morphology; distribution; hyperphosphorylation ... See more keywords
Constitutive regulation of mitochondrial morphology by Aurora A kinase depends on a predicted cryptic targeting sequence at the N-terminus
Sign Up to like & getrecommendations! Published in 2018 at "Open Biology"
DOI: 10.1098/rsob.170272
Abstract: Aurora A kinase (AURKA) is a major regulator of mitosis and an important driver of cancer progression. The roles of AURKA outside of mitosis, and how these might contribute to cancer progression, are not well… read more here.
Keywords: mitochondrial morphology; targeting sequence; aurora kinase; aurka ... See more keywords
Large-scale RNAi screen identified Dhpr as a regulator of mitochondrial morphology and tissue homeostasis
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aax0365
Abstract: Dhpr regulates mitochondrial morphology by modulating S-nitrosylation of Drp1. Mitochondria are highly dynamic organelles. Through a large-scale in vivo RNA interference (RNAi) screen that covered around a quarter of the Drosophila melanogaster genes (4000 genes),… read more here.
Keywords: large scale; mitochondrial morphology; morphology; morphology tissue ... See more keywords