Concurrent AFG3L2 and SPG7 mutations associated with syndromic parkinsonism and optic atrophy with aberrant OPA1 processing and mitochondrial network fragmentation
Sign Up to like & getrecommendations! Published in 2018 at "Human Mutation"
DOI: 10.1002/humu.23658
Abstract: Mitochondrial dynamics and quality control are crucial for neuronal survival and their perturbation is a major cause of neurodegeneration. m‐AAA complex is an ATP‐dependent metalloprotease located in the inner mitochondrial membrane and involved in protein… read more here.
Keywords: opa1 processing; mitochondrial network; optic atrophy; parkinsonism ... See more keywords
Studying Mitochondrial Network Formation by In Vivo and In Vitro Reconstitution Assay.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1266-8_25
Abstract: Mitochondria change their morphologies from small isolated vesicles to large continuous networks across the cell cycles. The mitochondrial network formation (MNF) plays an important role in maintaining mitochondrial DNA integrity and interchanging mitochondrial materials. The… read more here.
Keywords: network formation; network; vivo; mitochondrial network ... See more keywords
The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass
Sign Up to like & getrecommendations! Published in 2020 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-020-03662-0
Abstract: The dynamic coordination of processes controlling the quality of the mitochondrial network is crucial to maintain the function of mitochondria in skeletal muscle. Changes of mitochondrial proteolytic system, dynamics (fusion/fission), and mitophagy induce pathways that… read more here.
Keywords: muscle mass; muscle; mitochondrial network; regulation ... See more keywords
Spatiotemporal control of mitochondrial network dynamics in astroglial cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.06.191
Abstract: Mitochondria are increasingly recognized for playing important roles in regulating the evolving metabolic state of mammalian cells. This is particularly true for nerve cells, as dysregulation of mitochondrial dynamics is invariably associated with a number… read more here.
Keywords: control mitochondrial; mitochondrial network; network dynamics; dynamics astroglial ... See more keywords
Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.01.010
Abstract: SUMMARY Genetic and biochemical defects of mitochondrial function are a major cause of human disease, but their link to mitochondrial morphology in situ has not been defined. Here, we develop a quantitative three-dimensional approach to… read more here.
Keywords: quantitative mapping; network; mitochondrial network; muscle ... See more keywords
Estradiol and Estrogen Receptor-β Agonist Diarylpropionitrile Promote Mitochondrial Network fusion
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.269
Abstract: Estrogens exert many effects on mitochondrial function via targeting both nuclear and mitochondrial encoded genes. Recent reports indicate that the expression of mitochondrial fusion and fission proteins might be downstream targets of estradiol (E2). However,… read more here.
Keywords: network; mitochondrial network; promote mitochondrial; fusion ... See more keywords
Dynamic of mitochondrial network, cristae, and mitochondrial nucleoids in pancreatic β-cells.
Sign Up to like & getrecommendations! Published in 2019 at "Mitochondrion"
DOI: 10.1016/j.mito.2019.06.007
Abstract: Type 2 diabetes progression stems from dysfunction of β-cells, besides the peripheral insulin resistance. Mitochondria as glucose sensor and regulation center are impaired at various stages of this progression. Their biogenesis and functional impairment is… read more here.
Keywords: network; dynamic mitochondrial; mitochondrial network; cristae mitochondrial ... See more keywords
Mito Hacker: a set of tools to enable high-throughput analysis of mitochondrial network morphology
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-75899-5
Abstract: Mitochondria are highly dynamic organelles that can exhibit a wide range of morphologies. Mitochondrial morphology can differ significantly across cell types, reflecting different physiological needs, but can also change rapidly in response to stress or… read more here.
Keywords: network; mitochondrial network; morphology; cell ... See more keywords
Down Syndrome Critical Region 1 Gene, Rcan1, Helps Maintain a More Fused Mitochondrial Network
Sign Up to like & getrecommendations! Published in 2018 at "Circulation Research"
DOI: 10.1161/circresaha.117.311522
Abstract: Rationale: The regulator of calcineurin 1 (RCAN1) inhibits CN (calcineurin), a Ca2+-activated protein phosphatase important in cardiac remodeling. In humans, RCAN1 is located on chromosome 21 in proximity to the Down syndrome critical region. The… read more here.
Keywords: rcan1; syndrome critical; mitochondrial network; critical region ... See more keywords
Abstract 288: Mitoq Regulates Redox-related Non-coding Rnas to Improve Mitochondrial Network in Pressure Overload Heart Failure
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.288
Abstract: Background: Previous studies show that mitochondrial network excitability, or the propagation of ROS signals, is impaired in cardiomyocytes from failing hearts. While oxidative stress has been implicated in heart failure (HF)-associated mitochondrial network abnormality, the… read more here.
Keywords: pressure overload; network; mitochondrial network; coding rnas ... See more keywords
Mitochondrial Network State Scales mtDNA Genetic Dynamics.
Sign Up to like & getrecommendations! Published in 2019 at "Genetics"
DOI: 10.1534/genetics.119.302423
Abstract: Mitochondrial DNA (mtDNA) mutations cause severe congenital diseases but may also be associated with healthy aging. mtDNA is stochastically replicated and degraded, and exists within organelles which undergo dynamic fusion and fission. The role of… read more here.
Keywords: network; mitochondrial network; heteroplasmy; fusion ... See more keywords