Mitochondrial-nuclear communication by FKBP51 shuttling.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.30386
Abstract: The HSP90-binding immunophilin FKBP51 is a soluble protein that shows high homology and structural similarity with FKBP52. Both immunophilins are functionally divergent and often show antagonistic actions. They were first described in steroid receptor complexes,… read more here.
Keywords: cell; communication fkbp51; communication; fkbp51 ... See more keywords
Mitochondrial and nuclear disease panel (Mito‐aND‐Panel): Combined sequencing of mitochondrial and nuclear DNA by a cost‐effective and sensitive NGS‐based method
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.500
Abstract: The diagnosis of mitochondrial disorders is challenging because of the clinical variability and genetic heterogeneity of these conditions. Next‐Generation Sequencing (NGS) technology offers a robust high‐throughput platform for nuclear and mitochondrial DNA (mtDNA) analyses. read more here.
Keywords: disease panel; dna; panel mito; mitochondrial nuclear ... See more keywords
Mitochondrial and nuclear intraspecific variation in the rusty blenny (Parablennius sanguinolentus, Blenniidae)
Sign Up to like & getrecommendations! Published in 2017 at "Hydrobiologia"
DOI: 10.1007/s10750-017-3248-6
Abstract: The genetic structure of Parablennius sanguinolentus from the northeastern Atlantic and Mediterranean was assessed using sequences from the mitochondrial control region (CR) and the first intron of the nuclear S7 ribosomal protein gene (S7). Our… read more here.
Keywords: sanguinolentus; rusty blenny; parablennius sanguinolentus; mitochondrial nuclear ... See more keywords
Mitochondrial-nuclear cross-talk in the human brain is modulated by cell type and perturbed in neurodegenerative disease
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02792-w
Abstract: Mitochondrial dysfunction contributes to the pathogenesis of many neurodegenerative diseases. The mitochondrial genome encodes core respiratory chain proteins, but the vast majority of mitochondrial proteins are nuclear-encoded, making interactions between the two genomes vital for… read more here.
Keywords: modulated cell; human brain; disease; mitochondrial nuclear ... See more keywords
Mitophagy initiates retrograde mitochondrial-nuclear signaling to guide retinal pigment cell heterogeneity
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2109286
Abstract: ABSTRACT Age-related macular degeneration (AMD), the leading cause of blindness among the elderly, is without treatment for early disease. Degenerative retinal pigment epithelial (RPE) cell heterogeneity is a well-recognized but understudied pathogenic factor. Due to… read more here.
Keywords: rpe; retrograde mitochondrial; retinal pigment; mitochondrial nuclear ... See more keywords
Hierarchical integration of mitochondrial and nuclear positioning pathways by the Num1 EF hand.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e21-12-0610-t
Abstract: Positioning organelles at the right place and time is critical for their function and inheritance. In budding yeast, mitochondrial and nuclear positioning require the anchoring of mitochondria and dynein to the cell cortex by clusters… read more here.
Keywords: inheritance; positioning pathways; mitochondrial nuclear; hierarchical integration ... See more keywords
New Insights into Mitochondrial–Nuclear Interactions Revealed through Analysis of Small RNAs
Sign Up to like & getrecommendations! Published in 2022 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evac023
Abstract: Abstract Mitochondrial sequence variants affect phenotypic function, often through interaction with the nuclear genome. These “mitonuclear” interactions have been linked both to evolutionary processes and human health. The study of these interactions has focused on… read more here.
Keywords: interactions revealed; insights mitochondrial; nuclear interactions; mitochondrial nuclear ... See more keywords
Concerted regulation of mitochondrial and nuclear non‐coding RNAs by a dual‐targeted RNase Z
Sign Up to like & getrecommendations! Published in 2018 at "EMBO reports"
DOI: 10.15252/embr.201846198
Abstract: The molecular roles of the dually targeted ElaC domain protein 2 (ELAC2) during nuclear and mitochondrial RNA processing in vivo have not been distinguished. We generated conditional knockout mice of ELAC2 to identify that it… read more here.
Keywords: regulation mitochondrial; coding rnas; non; non coding ... See more keywords
Lack of transcriptional coordination between mitochondrial and nuclear oxidative phosphorylation genes in the presence of two divergent mitochondrial genomes
Sign Up to like & getrecommendations! Published in 2022 at "Zoological Research"
DOI: 10.24272/j.issn.2095-8137.2021.348
Abstract: In most eukaryotes, oxidative phosphorylation (OXPHOS) is the main energy production process and it involves both mitochondrial and nuclear genomes. The close interaction between the two genomes is critical for the coordinated function of the… read more here.
Keywords: oxphos; oxphos genes; nuclear oxphos; mitochondrial genomes ... See more keywords