Autoimmune neuroinflammation triggers mitochondrial oxidation in oligodendrocytes
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DOI: 10.1002/glia.24235
Abstract: Oligodendrocytes (ODCs) are myelinating cells of the central nervous system (CNS) supporting neuronal survival. Oxidants and mitochondrial dysfunction have been suggested as the main causes of ODC damage during neuroinflammation as observed in multiple sclerosis… read more here.
Keywords: oxidation; eae; neuroinflammation; odc mitochondria ... See more keywords
Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation
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DOI: 10.1038/s41467-021-27766-8
Abstract: Oxylipins are potent biological mediators requiring strict control, but how they are removed en masse during infection and inflammation is unknown. Here we show that lipopolysaccharide (LPS) dynamically enhances oxylipin removal via mitochondrial β-oxidation. Specifically,… read more here.
Keywords: oxidation; controlled mitochondrial; mitochondrial oxidation; oxylipin metabolism ... See more keywords