Activity regulates a cell type-specific mitochondrial phenotype in zebrafish lateral line hair cells
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.06.17.496604
Abstract: Hair cells of the inner ear are particularly sensitive to changes in mitochondria, the subcellular organelles necessary for energy production in all eukaryotic cells. There are over thirty mitochondrial deafness genes, and mitochondria are implicated… read more here.
Keywords: hair cell; mitochondrial phenotype; zebrafish lateral; hair cells ... See more keywords
A Heterozygous Mutation in MFF Associated with a Mild Mitochondrial Phenotype.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neuromuscular diseases"
DOI: 10.3233/jnd-221532
Abstract: BACKGROUND The number of mutations in nuclear encoded genes causing mitochondrial disease is ever increasing. Identification of these mutations is particularly important in the diagnosis of neuromuscular disorders as their presentation may mimic other acquired… read more here.
Keywords: mitochondrial fission; mff; mitochondrial phenotype; mild mitochondrial ... See more keywords
Presenilin-Deficient Neurons and Astrocytes Display Normal Mitochondrial Phenotypes
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2020.586108
Abstract: Presenilin 1 (PS1) and Presenilin 2 (PS2) are predominantly known as the catalytic subunits of the γ-secretase complex that generates the amyloid-β (Aβ) peptide, the major constituent of the senile plaques found in the brain… read more here.
Keywords: presenilin deficient; primary cultures; ps2; neurons astrocytes ... See more keywords
Mitochondrial Phenotype as a Driver of the Racial Dichotomy in Obesity and Insulin Resistance
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10061456
Abstract: African Americans (AA) are disproportionately burdened by metabolic diseases. While largely unexplored between Caucasian (C) and AA, differences in mitochondrial bioenergetics may provide crucial insight to mechanisms for increased susceptibility to metabolic diseases. AA display… read more here.
Keywords: mitochondrial phenotype; insulin resistance; phenotype driver; driver racial ... See more keywords